Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14637316 | 0.77 | TSHR (0.42) | HTR1AADRA1DADRA1AADRA1BTSHR | |
| SCHEMBL30501965 | 0.76 | CHRNB2 (0.43) | HTR1AADRA1DADRA1AADRA1BCYP2D6 | |
| SCHEMBL7097955 | 0.75 | HTR1A (0.33) | HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL30361752 | 0.72 | TACR1 (0.38) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL25190079 | 0.72 | TACR1 (0.38) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL31466275 | 0.70 | HTR1A (0.33) | HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL30888753 | 0.66 | KDM1A (0.38) | — | |
| SCHEMBL31253014 | 0.65 | HTR1A (0.39) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL1768148 | 0.65 | HTR1A (0.34) | HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL2489261 | 0.65 | HTR1A (0.34) | HTR1AADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024015406-A1 | INDOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-01-18 | — | — | WO | disclosed |