Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30729367 | 0.75 | HTR1A (0.37) | HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL30501965 | 0.74 | CHRNB2 (0.43) | HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL14637316 | 0.72 | TSHR (0.42) | HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL444346 | 0.70 | DRD2 (0.43) | HTR1A | |
| SCHEMBL25190079 | 0.68 | TACR1 (0.38) | HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL30361752 | 0.68 | TACR1 (0.38) | HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL15415997 | 0.65 | — | — | |
| SCHEMBL17654219 | 0.65 | — | — | |
| SCHEMBL1607384 | 0.64 | HRH1 (0.35) | — | |
| SCHEMBL15415974 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216244-B1 | Benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives useful as D4 antagonists | AVENTIS PHARMA INC (US) | 2003-08-13 | — | — | EP | disclosed |