Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.46 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 2/20 | 0.43 |
| ▸ | PLAU | P00749 | 2/20 | 0.43 |
| ▸ | ELANE | P08246 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.43 |
| ▸ | SI | P14410 | 1/20 | 0.43 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22633155 | 0.82 | KEAP1 (0.56) | ALDH1A1TSHRHSP90AA1MAPTMEN1 | |
| SCHEMBL26696761 | 0.82 | HSP90AA1 (0.48) | ALDH1A1TSHRHSP90AA1MAPTMEN1 | |
| SCHEMBL16799807 | 0.82 | KEAP1 (0.59) | HSP90AA1MAPTMEN1KMT2ARECQL | |
| SCHEMBL224389 | 0.81 | HSP90AA1 (0.62) | ALDH1A1HSP90AA1MAPTMEN1KMT2A | |
| SCHEMBL22633267 | 0.80 | EPHX2 (0.62) | HSP90AA1EPHX2MAPTMEN1KMT2A | |
| SCHEMBL26696816 | 0.79 | LMNA (0.45) | ALDH1A1TSHRHSP90AA1MAPTMEN1 | |
| SCHEMBL2120160 | 0.76 | HSP90AA1 (0.47) | ALDH1A1HSP90AA1MAPTMEN1KMT2A | |
| SCHEMBL22636605 | 0.74 | EPHX2 (0.54) | HSP90AA1EPHX2MEN1KMT2AKEAP1 | |
| SCHEMBL29833108 | 0.73 | KEAP1 (0.53) | TSHRHSP90AA1MAPTMEN1KMT2A | |
| SCHEMBL25347365 | 0.73 | ALKBH2 (0.61) | HSP90AA1MAPTF2PLAUELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113717154-B | Methods for treating huntington's disease | PTC医疗公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-110946865-B | Methods for treating huntington's disease | PTC医疗公司 | 2024-01-26 | — | — | CN | disclosed |