Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.77 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.77 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.77 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.77 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.77 |
| ▸ | GABRP | O00591 | 3/20 | 0.77 |
| ▸ | GABRD | O14764 | 3/20 | 0.77 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.77 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.77 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.77 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.77 |
| ▸ | GABRE | P78334 | 3/20 | 0.77 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.77 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.77 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.77 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.77 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.73 |
| ▸ | CNR1 | P21554 | 1/20 | 0.70 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| N-Desalkyl-2-Oxoquazepam SCHEMBL5177297 | 1.00 | LMNA (1.00) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| N-Desalkyl-2-Oxoquazepam SCHEMBL30529978 | 1.00 | LMNA (1.00) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL7323441 | 0.87 | LMNA (0.77) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| Delorazepam SCHEMBL29375434 | 0.87 | GABRA1 (1.00) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| Delorazepam SCHEMBL32681132 | 0.87 | GABRA1 (1.00) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| Delorazepam SCHEMBL157332 | 0.87 | GABRA1 (1.00) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL8547651 | 0.85 | GABRA1 (0.73) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL2615274 | 0.85 | GABRA1 (0.73) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL31696096 | 0.85 | GABRA1 (1.00) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL15435606 | 0.85 | GABRA1 (0.73) | LMNAGABRA1GABRA5GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4565225-A2 | PERIPHERALLY RESTRICTED GABA POSITIVE ALLOSTERIC MODULATORS FOR THE TREATMENT OF IRRITABLE BOWEL SYNDROME AND OTHER AILMENTS OF THE PERIPHERAL NERVOUS SYSTEM | The Johns Hopkins University (US) | 2025-06-11 | — | — | EP | disclosed |
| WO-2024030535-A2 | PERIPHERALLY RESTRICTED GABA POSITIVE ALLOSTERIC MODULATORS FOR THE TREATMENT OF IRRITABLE BOWEL SYNDROME AND OTHER AILMENTS OF THE PERIPHERAL NERVOUS SYSTEM | THE JOHNS HOPKINS UNIVERSITY (US) | 2024-02-08 | — | — | WO | disclosed |