Delorazepam

Delorazepam

SCHEMBL157332

O=C1CN=C(c2ccccc2Cl)c2cc(Cl)ccc2N1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 8/20 1.00
GABRA5 P31644 8/20 1.00
GABRA3 P34903 8/20 1.00
GABRA2 P47869 7/20 1.00
GABRB2 P47870 6/20 1.00
GABRG2 P18507 6/20 1.00
GABRB3 P28472 6/20 1.00
GABRP O00591 3/20 1.00
GABRD O14764 3/20 1.00
GABRB1 P18505 3/20 1.00
GABRA4 P48169 3/20 1.00
GABRE P78334 3/20 1.00
GABRA6 Q16445 3/20 1.00
GABRG1 Q8N1C3 3/20 1.00
GABRG3 Q99928 3/20 1.00
GABRQ Q9UN88 3/20 1.00
LMNA P02545 2/20 0.77
CNR1 P21554 1/20 0.74
NTSR1 P30989 1/20 0.74
OPRK1 P41145 1/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Delorazepam SCHEMBL32681132 1.00 GABRA1 (1.00) GABRA1GABRA5GABRA3GABRA2GABRB2
Delorazepam SCHEMBL29375434 1.00 GABRA1 (1.00) GABRA1GABRA5GABRA3GABRA2GABRB2
Delorazepam SCHEMBL29836158 0.90 GABRA1 (0.81) GABRA1GABRA5GABRA3GABRA2GABRB2
SCHEMBL7720989 0.87 GABRA1 (0.77) GABRA1GABRA5GABRA3GABRA2GABRB2
Phenazepam SCHEMBL416137 0.87 GABRA1 (1.00) GABRA1GABRA5GABRA3GABRA2GABRB2
7-Aminoclonazepam SCHEMBL11453747 0.87 GABRA1 (0.77) GABRA1GABRA5GABRA3GABRA2GABRB2
SCHEMBL9378946 0.87 GABRA1 (0.77) GABRA1GABRA5GABRA3GABRA2GABRB2
N-Desalkyl-2-Oxoquazepam SCHEMBL30730010 0.87 LMNA (1.00) GABRA1GABRA5GABRA3GABRA2GABRB2
SCHEMBL11772087 0.87 GABRA1 (0.77) GABRA1GABRA5GABRA3GABRA2GABRB2
SCHEMBL16144652 0.87 GABRA1 (0.77) GABRA1GABRA5GABRA3GABRA2GABRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1427 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260115161-A1 2-HYDROXY-OCTADECENE-9-CIS-OATE FOR USE IN THE TREATMENT OF ONCOLOGICAL PATHOLOGIES AND NEUROPATHIC PAIN LAMINAR PHARMACEUTICALS S A (ES) 2026-04-30 US claimed
US-20260062390-A1 CONTINUOUS FLOW SYNTHESIS OF LORAZEPAM PURDUE RESEARCH FOUNDATION 2026-03-05 US claimed
EP-4663187-A1 2-HYDROXY-OCTADECENE-9-CIS-OATE FOR USE IN THE TREATMENT OF ONCOLOGICAL PATHOLOGIES AND NEUROPATHIC PAIN Laminar Pharmaceuticals, S.A. (ES) 2025-12-17 EP claimed
WO-2025111482-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS BEXSON BIOMEDICAL, INC. (US) 2025-05-30 WO claimed
US-12133922-B2 Abuse resistant capsule R.P. SCHERER TECHNOLOGIES, LLC (US) 2024-11-05 US claimed
WO-2024189252-A1 2-HYDROXY-OCTADECENE-9-CIS-OATE FOR USE IN THE TREATMENT OF ONCOLOGICAL PATHOLOGIES AND NEUROPATHIC PAIN LAMINAR PHARMACEUTICALS S.A. (ES) 2024-09-19 WO claimed
US-20240197751-A1 Pharmaceutical composition and use thereof BARNAS, ARIAN JANKUR CAN (AT) 2024-06-20 US claimed
US-20240117436-A1 METHODS OF TREATING LIPEDEMA INCLUDING AKR1C2 AS A THERAPEUTIC TARGET MAGI EUREGIO SCS (IT) 2024-04-11 US claimed
WO-2024036115-A1 CONTINUOUS FLOW SYNTHESIS OF LORAZEPAM PURDUE RESEARCH FOUNDATION (US) 2024-02-15 WO claimed
US-20220362160-A1 ABUSE RESISTANT CAPSULE R.P. SCHERER TECHNOLOGIES, LLC (US) 2022-11-17 US claimed
EP-1515702-A1 ABUSE-PROTECTED ADMINISTRATION FORM Grünenthal GmbH (DE) 2005-03-23 EP claimed
WO-2004037230-A1 DOSAGE FORM THAT IS SAFEGUARDED FROM ABUSE Grünenthal GmbH (DE) 2004-05-06 WO claimed
WO-2004037259-A1 DOSAGE FORM THAT IS SAFEGUARDED FROM ABUSE Grünenthal GmbH (DE) 2004-05-06 WO claimed
US-20040052731-A1 Abuse-deterrent pharmaceutical compositions of opiods and other drugs COLLEGIUM PHARMACEUTICALS, INC. 2004-03-18 US claimed
WO-2004004693-A1 ABUSE-DETERRENT PHARMACEUTICAL COMPOSITIONS OF OPIODS AND OTHER DRUGS COLLGEGIUM PHARMACEUTICAL (US) 2004-01-15 WO claimed
WO-2003105808-A1 ABUSE-PROTECTED ADMINISTRATION FORM Grünenthal GmbH (DE) 2003-12-24 WO claimed
WO-2003004015-A1 OIL-IN-WATER EMULSIONS COMPRISING A BENZODIAZEPINE DRUG WEST PHARMACEUTICAL SERVICES DRUG DELIVERY & CLINICAL RESEARCH CENTRE LIMITED (GB) 2003-01-16 WO claimed
EP-1273301-A2 Pharmaceutical preparations based on active ingredients susceptible to illicit administration ALTERGON S.A. (CH) 2003-01-08 EP claimed
US-4595684-A Method of suppressing benzodiazepine induced sedation with 2-(p-methoxypenyl)-pyrazolo[4,3-c]quinolin-3(5H)-one or a salt thereof CIBA-GEIGY CORPORATION (US) 1986-06-17 US claimed
US-4511510-A PHTHALIMIDOGLYCINE, HYDRAZINE RAVIZZA S.P.A. (IT) 1985-04-16 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260062390-A1 CONTINUOUS FLOW SYNTHESIS OF LORAZEPAM GRIK4, GRIK5, POLM GABRA1 201/4885GABRA5 58/4885GABRA3 192/4885
US-20260115161-A1 2-HYDROXY-OCTADECENE-9-CIS-OATE FOR USE IN THE TREATMENT OF ONCOLOGICAL PATHOLOGIES AND NEUROPATHIC PAIN PMP22, VHL, PAX8 GABRA1 4061/4885GABRA5 4152/4885GABRA3 3603/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.