Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 7/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 5/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.36 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.35 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.35 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22553865 | 1.00 | SMN1; SMN2 (0.42) | SMN1; SMN2NPC1HTTTGFBR1ACVR1 | |
| SCHEMBL30730803 | 0.87 | SMN1; SMN2 (0.41) | SMN1; SMN2NPC1HTTTGFBR1CHEK1 | |
| SCHEMBL22553792 | 0.87 | SMN1; SMN2 (0.41) | SMN1; SMN2NPC1HTTTGFBR1CHEK1 | |
| SCHEMBL22578371 | 0.86 | TGFBR1 (0.52) | TGFBR1ACVR1FYNRIPK2NOD2 | |
| SCHEMBL22553914 | 0.84 | SMN1; SMN2 (0.42) | SMN1; SMN2NPC1HTTTGFBR1ACVR1 | |
| SCHEMBL30730782 | 0.84 | SMN1; SMN2 (0.42) | SMN1; SMN2NPC1HTTTGFBR1ACVR1 | |
| SCHEMBL30730794 | 0.83 | PRKAB2 (0.41) | SMN1; SMN2NPC1HTTTGFBR1ACVR1 | |
| SCHEMBL22554202 | 0.83 | PRKAB2 (0.41) | SMN1; SMN2NPC1HTTTGFBR1ACVR1 | |
| SCHEMBL22553751 | 0.73 | TBK1 (0.41) | SMN1; SMN2NPC1HTTTGFBR1ACVR1 | |
| SCHEMBL30730839 | 0.73 | TBK1 (0.41) | SMN1; SMN2NPC1HTTTGFBR1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112088157-B | Aryl-bipyridylamine derivatives as phosphatidylinositol phosphokinase inhibitors | 拉文纳制药公司 | 2023-12-26 | — | — | CN | claimed |
| CN-112088157-B | Aryl-bipyridylamine derivatives as phosphatidylinositol phosphokinase inhibitors | 拉文纳制药公司 | 2023-12-26 | — | — | CN | disclosed |