Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.38 |
| ▸ | HTR2C | P28335 | 5/20 | 0.38 |
| ▸ | HTR2B | P41595 | 5/20 | 0.38 |
| ▸ | CYBB | P04839 | 1/20 | 0.35 |
| ▸ | NCF1 | P14598 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | DHPS | P49366 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.34 |
| ▸ | DCK | P27707 | 4/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26977593 | 1.00 | HTR2A (0.38) | HTR2AHTR2CHTR2BCYBBNCF1 | |
| SCHEMBL29778792 | 0.82 | CYBB (0.35) | HTR2ACYBBNCF1PIK3CADHPS | |
| SCHEMBL23641394 | 0.82 | CYBB (0.35) | HTR2ACYBBNCF1PIK3CADHPS | |
| SCHEMBL34470794 | 0.81 | HTR2A (0.35) | HTR2AHTR2CHTR2BPIK3CAHDAC1 | |
| SCHEMBL20354807 | 0.80 | HTR2A (0.42) | HTR2AHTR2CHTR2BCYBBNCF1 | |
| SCHEMBL29903816 | 0.80 | HTR2A (0.42) | HTR2AHTR2CHTR2BCYBBNCF1 | |
| SCHEMBL21608777 | 0.80 | P2RX3 (0.36) | HTR2APIK3CAP2RX3P2RX2 | |
| SCHEMBL30723514 | 0.80 | P2RX3 (0.36) | HTR2APIK3CAP2RX3P2RX2 | |
| SCHEMBL26978045 | 0.74 | NUDT1 (0.46) | P2RX3P2RX2 | |
| SCHEMBL27038877 | 0.74 | P2RX3 (0.35) | PIK3CAP2RX3P2RX2PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4558498-A1 | NOVEL IMIDAZOPYRIDINE AND PYRAZOLOPYRIDINE SULFONAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2025-05-28 | — | — | EP | disclosed |
| CN-119546608-A | Novel imidazopyridine and pyrazolopyridine sulfonamide derivatives | 豪夫迈·罗氏有限公司 | 2025-02-28 | — | — | CN | disclosed |
| CN-119546576-A | Novel isoquinolinones pyrrolo-pyridones and thieno pyridone sulfonamide derivatives | 豪夫迈·罗氏有限公司 | 2025-02-28 | — | — | CN | disclosed |
| WO-2024017857-A1 | NOVEL IMIDAZOPYRIDINE AND PYRAZOLOPYRIDINE SULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2024-01-25 | — | — | WO | disclosed |