Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | BACE1 | P56817 | 3/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.33 |
| ▸ | REN | P00797 | 2/20 | 0.33 |
| ▸ | CTSD | P07339 | 2/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | ACACB | O00763 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30723514 | 1.00 | P2RX3 (0.36) | P2RX3P2RX2PIK3CAPIK3CGPIK3CD | |
| SCHEMBL34471808 | 0.82 | ACACB (0.31) | ACACBEGFRKDR | |
| SCHEMBL29778792 | 0.81 | CYBB (0.35) | P2RX3P2RX2PIK3CAPIK3CGPIK3CD | |
| SCHEMBL23641394 | 0.81 | CYBB (0.35) | P2RX3P2RX2PIK3CAPIK3CGPIK3CD | |
| SCHEMBL21608759 | 0.81 | BACE1 (0.33) | P2RX3P2RX2SCN9ABACE1BACE2 | |
| SCHEMBL29778825 | 0.81 | BACE1 (0.33) | P2RX3P2RX2SCN9ABACE1BACE2 | |
| SCHEMBL30731668 | 0.80 | HTR2A (0.38) | P2RX3P2RX2PIK3CAHTR2A | |
| SCHEMBL26977593 | 0.80 | HTR2A (0.38) | P2RX3P2RX2PIK3CAHTR2A | |
| SCHEMBL27038877 | 0.80 | P2RX3 (0.35) | P2RX3P2RX2PIK3CAPIK3CGPIK3CD | |
| SCHEMBL30559743 | 0.75 | NUDT1 (0.44) | P2RX3P2RX2MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260027104-A1 | NOVEL NAPHTHYL AND ISOQUINOLINE SULFONAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2026-01-29 | — | — | US | disclosed |
| US-20250296931-A1 | NOVEL ISOQUINOLINONE, PYRROLOPYRIDINONE AND THIENOPYRIDINONE SULFONAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2025-09-25 | — | — | US | disclosed |
| EP-4558483-A1 | NOVEL ISOQUINOLINONE, PYRROLOPYRIDINONE AND THIENOPYRIDINONE SULFONAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2025-05-28 | — | — | EP | disclosed |
| EP-4558479-A1 | NOVEL NAPHTHYL AND ISOQUINOLINE SULFONAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2025-05-28 | — | — | EP | disclosed |
| WO-2024115733-A1 | FUSED PYRROLYL-SULFONAMIDE COMPOUNDS | REWIND THERAPEUTICS NV (BE) | 2024-06-06 | — | — | WO | disclosed |
| US-11976056-B2 | Substituted alkoxypyridinyl indolsulfonamides | UCB PHARMA GMBH (DE) | 2024-05-07 | — | — | US | disclosed |
| WO-2024017856-A1 | NOVEL ISOQUINOLINONE, PYRROLOPYRIDINONE AND THIENOPYRIDINONE SULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2024-01-25 | — | — | WO | disclosed |
| WO-2024017856-A1 | NOVEL ISOQUINOLINONE, PYRROLOPYRIDINONE AND THIENOPYRIDINONE SULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2024-01-25 | — | — | WO | disclosed |
| WO-2024017858-A1 | NOVEL NAPHTHYL AND ISOQUINOLINE SULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2024-01-25 | — | — | WO | disclosed |
| WO-2024017858-A1 | NOVEL NAPHTHYL AND ISOQUINOLINE SULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2024-01-25 | — | — | WO | disclosed |
| WO-2024017857-A1 | NOVEL IMIDAZOPYRIDINE AND PYRAZOLOPYRIDINE SULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2024-01-25 | — | — | WO | disclosed |
| EP-4086248-A1 | SUBSTITUTED ALKOXYPYRIDINYL INDOLSULFONAMIDES | UCB Pharma GmbH (DE) | 2022-11-09 | — | — | EP | disclosed |
| EP-3810587-B1 | SUBSTITUTED ALKOXYPYRIDINYL INDOLSULFONAMIDES | UCB PHARMA GMBH (DE) | 2022-08-10 | — | — | EP | disclosed |
| US-20210214337-A1 | SUBSTITUTED ALKOXYPYRIDINYL INDOLSULFONAMIDES | UCB PHARMA GMBH (DE) | 2021-07-15 | — | — | US | disclosed |
| WO-2019243398-A1 | SUBSTITUTED ALKOXYPYRIDINYL INDOLSULFONAMIDES | UCB PHARMA GMBH (DE) | 2019-12-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250296931-A1 | NOVEL ISOQUINOLINONE, PYRROLOPYRIDINONE AND THIENOPYRIDINONE SULFONAMIDE DERIVATIVES | SULT1E1, XDH, PRXL2A | P2RX3 188/4885P2RX2 323/4885PIK3CA 637/4885 |
| US-20260027104-A1 | NOVEL NAPHTHYL AND ISOQUINOLINE SULFONAMIDE DERIVATIVES | CBR3, HAX1, CBR1 | P2RX3 671/4885P2RX2 1034/4885PIK3CA 3320/4885 |
| US-20210214337-A1 | SUBSTITUTED ALKOXYPYRIDINYL INDOLSULFONAMIDES | GPR119, GPR17, GPR27 | P2RX3 537/4885P2RX2 560/4885PIK3CA 2521/4885 |
| US-11976056-B2 | Substituted alkoxypyridinyl indolsulfonamides | GPR119, GPR17, GPR27 | P2RX3 537/4885P2RX2 560/4885PIK3CA 2521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.