Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ACLY | P53396 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26969718 | 0.84 | HDAC1 (0.49) | HDAC1HDAC6HDAC8MEN1KMT2A | |
| SCHEMBL30733402 | 0.81 | HDAC1 (0.48) | HDAC1HDAC6SIGMAR1TSHRCYP2D6 | |
| SCHEMBL30733404 | 0.78 | HDAC1 (0.43) | HDAC1HDAC6SIGMAR1TSHRCYP2D6 | |
| SCHEMBL30733426 | 0.77 | HDAC1 (0.52) | HDAC1HDAC6SIGMAR1TSHRCYP2D6 | |
| SCHEMBL26969774 | 0.74 | CYP3A4 (0.48) | HDAC1HDAC6TSHRCYP2D6TP53 | |
| SCHEMBL25276068 | 0.74 | KMT2A (0.43) | TSHRTP53ALDH1A1ACLYHTR2C | |
| SCHEMBL30733411 | 0.72 | SIGMAR1 (0.46) | HDAC1HDAC6SIGMAR1TSHRCYP2D6 | |
| SCHEMBL26969759 | 0.72 | KDM4E (0.41) | HDAC1HDAC6TSHRCYP2D6TP53 | |
| SCHEMBL26969709 | 0.71 | CXCR4 (0.43) | TSHRCYP2D6CYP3A4ALDH1A1MEN1 | |
| SCHEMBL1980590 | 0.70 | HDAC1 (0.68) | HDAC1HDAC6SIGMAR1TSHRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230416262-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. | 2023-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230416262-A1 | TRPML MODULATORS | TRPM2, TRPM4, TRPM5 | HDAC1 2067/4885HDAC6 526/4885SIGMAR1 683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.