Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | BACE1 | P56817 | 1/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 10/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.50 |
| ▸ | USP2 | O75604 | 5/20 | 0.50 |
| ▸ | AKT1 | P31749 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31485157 | 0.85 | PIK3CD (0.49) | MAP4K4 | |
| SCHEMBL4354995 | 0.83 | ACHE (0.58) | ACHEBACE1CLK4CYP3A4HIF1A | |
| SCHEMBL4358571 | 0.83 | AKT1 (0.65) | ACHEBACE1CLK4CYP3A4HIF1A | |
| SCHEMBL30734156 | 0.82 | ALDH1A1 (0.50) | CLK4CYP3A4HIF1AALDH1A1CYP1A2 | |
| SCHEMBL30734169 | 0.82 | CYP3A4 (0.54) | CLK4CYP3A4HIF1AALDH1A1CYP1A2 | |
| SCHEMBL31485220 | 0.82 | CASP6 (0.48) | CYP3A4 | |
| SCHEMBL31485146 | 0.81 | PIK3CA (0.47) | MAP4K4 | |
| SCHEMBL4356104 | 0.81 | ACHE (0.56) | ACHEBACE1CLK4CYP3A4HIF1A | |
| SCHEMBL30734232 | 0.81 | ALDH1A1 (0.49) | ACHEBACE1CLK4CYP3A4HIF1A | |
| SCHEMBL30734231 | 0.81 | CYP3A4 (0.52) | CLK4CYP3A4HIF1AALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543888-A1 | SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF | Arizona Board of Regents on behalf of The University of Arizona (US) | 2025-04-30 | — | — | EP | disclosed |
| WO-2023250083-A1 | SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2023-12-28 | — | — | WO | disclosed |