Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | BACE1 | P56817 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 10/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 8/20 | 0.49 |
| ▸ | LMNA | P02545 | 7/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.48 |
| ▸ | USP2 | O75604 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30734232 | 0.89 | ALDH1A1 (0.49) | ACHEBACE1CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL30734187 | 0.89 | ACHE (0.53) | ACHEBACE1CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL30734231 | 0.89 | CYP3A4 (0.52) | CYP1A2CYP3A4ALDH1A1CLK4LMNA | |
| SCHEMBL30734134 | 0.86 | ACHE (0.58) | ACHEBACE1CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL30734212 | 0.86 | HTT (0.49) | CYP1A2CYP3A4ALDH1A1CLK4LMNA | |
| SCHEMBL30734241 | 0.84 | MAPKAPK2 (0.53) | ALDH1A1LMNAMAPK1MAPTHTT | |
| SCHEMBL31745229 | 0.83 | CYP1A2 (0.52) | CYP1A2CYP3A4ALDH1A1CLK4LMNA | |
| SCHEMBL4358134 | 0.83 | ACHE (0.61) | ACHEBACE1CYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL30734169 | 0.83 | CYP3A4 (0.54) | CYP1A2CYP3A4ALDH1A1CLK4LMNA | |
| SCHEMBL30734221 | 0.83 | LMNA (0.51) | CYP1A2CYP3A4ALDH1A1CLK4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250382301-A1 | SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF | UNIV ARIZONA (US) | 2025-12-18 | — | — | US | disclosed |
| EP-4543888-A1 | SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF | Arizona Board of Regents on behalf of The University of Arizona (US) | 2025-04-30 | — | — | EP | disclosed |
| WO-2023250083-A1 | SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2023-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250382301-A1 | SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF | CLK2, CLK3, CLK1 | ACHE 3704/4885BACE1 1412/4885CYP1A2 3648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.