Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | FABP6 | P51161 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.33 |
| ▸ | FEN1 | P39748 | 5/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20153298 | 0.73 | ALDH1A1 (0.42) | ALDH1A1GAAHSD17B10MAPTGRM5 | |
| SCHEMBL30657929 | 0.73 | GRM5 (0.54) | ALDH1A1GAAHSD17B10MAPTGRM5 | |
| SCHEMBL91447 | 0.73 | GRM5 (0.54) | ALDH1A1GAAHSD17B10MAPTGRM5 | |
| SCHEMBL27325551 | 0.72 | NLRP3 (0.41) | ALDH1A1GAAHSD17B10MAPTGRM5 | |
| SCHEMBL30960159 | 0.72 | UHRF1 (0.49) | ALDH1A1GAAHSD17B10MAPTKDM4E | |
| SCHEMBL2492111 | 0.70 | GAA (0.47) | ALDH1A1GAAHSD17B10MAPTGRM5 | |
| SCHEMBL13424834 | 0.70 | ALDH1A1 (0.40) | ALDH1A1GAAHSD17B10MAPTGRM5 | |
| SCHEMBL21605829 | 0.70 | ALDH1A1 (0.40) | ALDH1A1GAAHSD17B10MAPTGRM5 | |
| SCHEMBL5757962 | 0.69 | GRM5 (0.40) | ALDH1A1GAAHSD17B10MAPTGRM5 | |
| SCHEMBL4343282 | 0.69 | ALDH1A1 (0.50) | ALDH1A1GAAHSD17B10MAPTGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4547663-A1 | IMIDAZO[4,5-C]PYRIDINE DERIVATIVES AS SIK MODULATORS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS | F. Hoffmann-La Roche AG (CH) | 2025-05-07 | — | — | EP | disclosed |
| US-20250115607-A1 | PYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2025-04-10 | — | — | US | disclosed |
| CN-119451959-A | Imidazo [4,5-C ] pyridine derivatives as SIK modulators for the treatment of rheumatoid arthritis | 豪夫迈·罗氏有限公司 | 2025-02-14 | — | — | CN | disclosed |
| WO-2024003209-A1 | IMIDAZO[4,5-C]PYRIDINE DERIVATIVES AS SIK MODULATORS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS | F. HOFFMANN-LA ROCHE AG (CH) | 2024-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250115607-A1 | PYRIDINE DERIVATIVES | ADORA1, CYP1A1, MT-ND1 | ALDH1A1 130/4885GAA 3070/4885HSD17B10 2690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.