SCHEMBL30737175

SCHEMBL30737175

CNC(=O)c1ccc2c(Oc3ccc(C(=O)N[C@@H](CCC(C)(C)C)C(=O)O)cn3)cccc2c1

nearest known ligand 0.64

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SORT1 Q99523 5/20 0.64
GRN P28799 4/20 0.64
HPGDS O60760 1/20 0.40
OPRM1 P35372 1/20 0.38
OPRD1 P41143 1/20 0.38
BCL2L1 Q07817 1/20 0.37
GRM5 P41594 1/20 0.37
PYGL P06737 1/20 0.37
CYP2C9 P11712 1/20 0.37
GPR132 Q9UNW8 3/20 0.36
GABRA5 P31644 3/20 0.36
CTSA P10619 1/20 0.36
PIN1 Q13526 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27291768 0.91 SORT1 (0.65) SORT1GRNOPRM1OPRD1BCL2L1
SCHEMBL30737257 0.86 SORT1 (0.66) SORT1GRNOPRM1OPRD1BCL2L1
SCHEMBL30737313 0.85 SORT1 (0.79) SORT1GRNOPRM1OPRD1GPR132
SCHEMBL30737363 0.81 HPGDS (0.51) HPGDSOPRM1OPRD1
SCHEMBL25273962 0.79 SORT1 (1.00) SORT1GRNHPGDSOPRM1OPRD1
SCHEMBL24283502 0.79 SORT1 (1.00) SORT1GRNHPGDSOPRM1OPRD1
SCHEMBL30737479 0.78 HPGDS (0.53) HPGDSOPRM1OPRD1
SCHEMBL30737249 0.78 HPGDS (0.50) HPGDSOPRM1OPRD1
SCHEMBL30737318 0.76 SORT1 (0.77) SORT1GRNOPRM1OPRD1GRM5
SCHEMBL30737250 0.73 SORT1 (0.73) SORT1GRNOPRM1OPRD1GRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4543858-A1 BIFUNCTIONAL MOLECULES THAT SELECTIVELY INDUCE DEGRADATION OF EXTRACELLULAR TARGETS IN LYSOSOMES Draupnir Bio ApS (DK) 2025-04-30 EP disclosed
WO-2023247754-A1 BIFUNCTIONAL MOLECULES THAT SELECTIVELY INDUCE DEGRADATION OF EXTRACELLULAR TARGETS IN LYSOSOMES DRAUPNIR BIO APS (DK) 2023-12-28 WO disclosed