SCHEMBL30737737

SCHEMBL30737737

CC(=O)c1ccc(C#N)c(C)c1

nearest known ligand 0.51

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
S1PR3 Q99500 11/20 0.51
AR P10275 1/20 0.43
CYP11B1 P15538 1/20 0.43
CYP11B2 P19099 1/20 0.43
MEN1 O00255 1/20 0.43
APAF1 O14727 1/20 0.43
KMT2A Q03164 1/20 0.43
CYP2A6 P11509 1/20 0.43
MRGPRX4 Q96LA9 1/20 0.43
S1PR1 P21453 4/20 0.42
S1PR2 O95136 1/20 0.42
S1PR4 O95977 1/20 0.42
TSHR P16473 1/20 0.42
ALDH1A1 P00352 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2369495 1.00 S1PR3 (0.51) S1PR3ARCYP11B1CYP11B2MEN1
SCHEMBL996704 0.85 MRGPRX4 (0.56) S1PR3MEN1KMT2AMRGPRX4TSHR
SCHEMBL7662707 0.85 VNN1 (0.45) S1PR3CYP11B1CYP11B2MEN1APAF1
SCHEMBL16961084 0.84 S1PR3 (0.47) S1PR3ARMRGPRX4S1PR1S1PR2
SCHEMBL2767509 0.83 S1PR3 (0.50) S1PR3ARCYP11B2MRGPRX4S1PR1
SCHEMBL1275282 0.83 S1PR3 (0.54) S1PR3S1PR1S1PR2S1PR4
SCHEMBL2620548 0.81 CYP2A6 (0.43) S1PR3KMT2ACYP2A6ALDH1A1
SCHEMBL10412463 0.81 CYP2A6 (0.43) S1PR3KMT2ACYP2A6TSHRALDH1A1
SCHEMBL18724341 0.81 S1PR3 (0.44) S1PR3ARMRGPRX4S1PR1S1PR2
SCHEMBL6970906 0.81 PKM (0.46) CYP11B1CYP11B2MEN1APAF1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119751370-A Preparation method of fluororalrana 河北威远药业有限公司 2025-04-04 CN claimed
CN-117510428-A Preparation process method of isoxazoline substituted benzamide compound 中国农业大学 2024-02-06 CN claimed
CN-119751370-A Preparation method of fluororalrana 河北威远药业有限公司 2025-04-04 CN disclosed
WO-2025003945-A1 AN IMPROVED PROCESS FOR THE PREPARATION OF 4-ACETYL-2-METHYL-BENZONITRILE HIKAL LIMITED (IN) 2025-01-02 WO disclosed
CN-119019281-A Preparation method of 4-acetyl-2-methylbenzonitrile 黑龙江立科新材料有限公司 2024-11-26 CN disclosed
CN-117510428-A Preparation process method of isoxazoline substituted benzamide compound 中国农业大学 2024-02-06 CN disclosed