Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 4/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.48 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | ITK | Q08881 | 4/20 | 0.42 |
| ▸ | AURKA | O14965 | 3/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30739056 | 0.90 | KLKB1 (0.50) | KLKB1GRM2ITKSCDELANE | |
| SCHEMBL20529831 | 0.86 | KLKB1 (0.52) | KLKB1GRM2ITKSCDELANE | |
| SCHEMBL31591059 | 0.84 | KLKB1 (0.52) | KLKB1CREBBPPOLBITKAURKA | |
| SCHEMBL30739156 | 0.84 | KLKB1 (0.51) | KLKB1GRM2ITKSCDELANE | |
| SCHEMBL30739164 | 0.84 | KLKB1 (0.51) | KLKB1GRM2ITKSCDELANE | |
| SCHEMBL30739112 | 0.81 | GRM2 (0.44) | KLKB1GRM2GRM5ALDH1A1LMNA | |
| SCHEMBL553848 | 0.80 | ALDH1A1 (0.60) | KLKB1CREBBPGRM2ALDH1A1LMNA | |
| SCHEMBL30739083 | 0.80 | GRM2 (0.48) | KLKB1GRM2ALDH1A1LMNA | |
| SCHEMBL1909166 | 0.79 | GRM2 (0.53) | KLKB1GRM2ALDH1A1LMNA | |
| SCHEMBL30739047 | 0.79 | GRM2 (0.43) | KLKB1GRM2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4561993-A1 | INHIBITORS OF PLASMA KALLIKREIN | Rezolute, Inc. (US) | 2025-06-04 | — | — | EP | disclosed |
| CN-120051460-A | Plasma kallikrein inhibitors | 瑞泽路特有限公司 | 2025-05-27 | — | — | CN | disclosed |
| WO-2024025907-A1 | INHIBITORS OF PLASMA KALLIKREIN | REZOLUTE, INC. (US) | 2024-02-01 | — | — | WO | disclosed |