Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 8/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30739112 | 0.88 | GRM2 (0.44) | GRM2KLKB1TDP1MAPTALDH1A1 | |
| SCHEMBL20529831 | 0.87 | KLKB1 (0.52) | GRM2KLKB1TDP1MAPTALDH1A1 | |
| SCHEMBL30739156 | 0.85 | KLKB1 (0.51) | GRM2KLKB1TDP1MAPTLMNA | |
| SCHEMBL30739164 | 0.85 | KLKB1 (0.51) | GRM2KLKB1TDP1MAPTLMNA | |
| SCHEMBL31591078 | 0.84 | KLKB1 (0.43) | KLKB1MAPTALDH1A1LMNA | |
| SCHEMBL30739056 | 0.84 | KLKB1 (0.50) | GRM2KLKB1TDP1MAPTALDH1A1 | |
| SCHEMBL30739083 | 0.80 | GRM2 (0.48) | GRM2KLKB1MAPTALDH1A1HTT | |
| SCHEMBL1909166 | 0.80 | GRM2 (0.53) | GRM2KLKB1ALDH1A1LMNANPC1 | |
| SCHEMBL30739032 | 0.79 | KLKB1 (0.50) | GRM2KLKB1ALDH1A1LMNA | |
| SCHEMBL2821953 | 0.79 | LMNA (0.54) | GRM2KLKB1TDP1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4561993-A1 | INHIBITORS OF PLASMA KALLIKREIN | Rezolute, Inc. (US) | 2025-06-04 | — | — | EP | disclosed |
| CN-120051460-A | Plasma kallikrein inhibitors | 瑞泽路特有限公司 | 2025-05-27 | — | — | CN | disclosed |
| WO-2024025907-A1 | INHIBITORS OF PLASMA KALLIKREIN | REZOLUTE, INC. (US) | 2024-02-01 | — | — | WO | disclosed |