Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 8/20 | 0.45 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | F3 | P13726 | 1/20 | 0.36 |
| ▸ | KLK1 | P06870 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.35 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30739059 | 0.88 | KLKB1 (0.47) | KLKB1F10CYP3A4GPR142MAPK11 | |
| SCHEMBL30739314 | 0.88 | KLKB1 (0.42) | KLKB1F10MAPK11MAPK14L3MBTL1 | |
| SCHEMBL30739167 | 0.87 | KLKB1 (0.37) | KLKB1CYP3A4GPR142F2ALDH1A1 | |
| SCHEMBL30739114 | 0.82 | KLKB1 (0.46) | KLKB1F10MAPK11MAPK14F2 | |
| SCHEMBL31591085 | 0.81 | TSHR (0.46) | NPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL30739420 | 0.80 | NPC1 (0.40) | CYP3A4L3MBTL1KDM4ENPC1ALDH1A1 | |
| SCHEMBL30739146 | 0.75 | KLKB1 (0.77) | KLKB1KLK1KDM4EALDH1A1 | |
| SCHEMBL30739063 | 0.71 | KLKB1 (0.77) | KLKB1KLK1 | |
| SCHEMBL30739085 | 0.71 | KLKB1 (0.51) | KLKB1F10TPSAB1LOXLOXL2 | |
| SCHEMBL30739043 | 0.71 | KLKB1 (0.63) | KLKB1F2KLK1SMN1; SMN2TPSAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4561993-A1 | INHIBITORS OF PLASMA KALLIKREIN | Rezolute, Inc. (US) | 2025-06-04 | — | — | EP | disclosed |
| WO-2024025907-A1 | INHIBITORS OF PLASMA KALLIKREIN | REZOLUTE, INC. (US) | 2024-02-01 | — | — | WO | disclosed |