Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 6/20 | 0.47 |
| ▸ | F10 | P00742 | 2/20 | 0.40 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 3/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | F7 | P08709 | 1/20 | 0.39 |
| ▸ | F3 | P13726 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.37 |
| ▸ | KLK1 | P06870 | 1/20 | 0.37 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30739113 | 0.88 | KLKB1 (0.45) | KLKB1F10F2MAPK11MAPK14 | |
| SCHEMBL30739314 | 0.85 | KLKB1 (0.42) | KLKB1F10MAPK11MAPK14L3MBTL1 | |
| SCHEMBL31591077 | 0.81 | TSHR (0.48) | KLKB1MAPK14ALOX15L3MBTL1 | |
| SCHEMBL30739057 | 0.80 | NPC1 (0.42) | L3MBTL1CYP3A4 | |
| SCHEMBL30739119 | 0.79 | KLKB1 (0.76) | KLKB1KLK1 | |
| SCHEMBL30739167 | 0.76 | KLKB1 (0.37) | KLKB1F2CYP3A4GPR142 | |
| SCHEMBL30739063 | 0.73 | KLKB1 (0.77) | KLKB1KLK1 | |
| SCHEMBL368793 | 0.72 | NPBWR1 (0.45) | ALOX15L3MBTL1PTGER4 | |
| SCHEMBL30739173 | 0.72 | NPC1 (0.42) | L3MBTL1 | |
| SCHEMBL30739045 | 0.71 | KLKB1 (0.72) | KLKB1F10KLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4561993-A1 | INHIBITORS OF PLASMA KALLIKREIN | Rezolute, Inc. (US) | 2025-06-04 | — | — | EP | disclosed |
| WO-2024025907-A1 | INHIBITORS OF PLASMA KALLIKREIN | REZOLUTE, INC. (US) | 2024-02-01 | — | — | WO | disclosed |