SCHEMBL30740950

SCHEMBL30740950

COc1c(F)cc(C(=O)O)cc1C(F)(F)F

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.47
MAPK1 P28482 1/20 0.47
HTT P42858 1/20 0.47
RAB9A P51151 1/20 0.47
TPMT P51580 5/20 0.44
PTGS2 P35354 1/20 0.42
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA3 P07451 1/20 0.41
PKM P14618 1/20 0.41
CA4 P22748 1/20 0.41
CA6 P23280 1/20 0.41
CA5A P35218 1/20 0.41
CA7 P43166 1/20 0.41
CA9 Q16790 1/20 0.41
CA14 Q9ULX7 1/20 0.41
CA5B Q9Y2D0 1/20 0.41
TUBB1 Q9H4B7 2/20 0.38
MRGPRX4 Q96LA9 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17400517 0.87 KIF11 (0.46) LMNAMAPK1HTTRAB9ACA5A
SCHEMBL1458628 0.84 LMNA (0.58) LMNAMAPK1HTTRAB9ATPMT
SCHEMBL1458336 0.82 TPMT (0.61) LMNAHTTTPMTCA12CA1
SCHEMBL10322710 0.80 TPMT (0.41) LMNAMAPK1HTTRAB9ATPMT
SCHEMBL10323913 0.80 TPMT (0.41) LMNAHTTTPMTPTGS2CA12
SCHEMBL23699520 0.79 LMNA (0.50) LMNAMAPK1HTTRAB9ATPMT
SCHEMBL10323576 0.78 CYP2C9 (0.42) TPMT
SCHEMBL1561256 0.77 TPMT (0.66) LMNAMAPK1HTTRAB9ATPMT
SCHEMBL12648268 0.77 TPMT (0.66) LMNAMAPK1HTTRAB9ATPMT
SCHEMBL10323353 0.77 SMN1; SMN2 (0.40) RAB9ATPMTPTGS2CA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260035341-A1 FTO INHIBITORS RPXDS CO LTD (CN) 2026-02-05 US disclosed
EP-4561975-A1 FTO INHIBITORS RPXDS Co., Ltd (CN) 2025-06-04 EP disclosed
CN-119546566-A FTO inhibitors 瑞璞鑫(苏州)生物科技有限公司 2025-02-28 CN disclosed
WO-2024022491-A1 FTO INHIBITORS RPXDS CO., LTD (CN) 2024-02-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260035341-A1 FTO INHIBITORS FTO, LDLR, GPR119 LMNA 1168/4885MAPK1 1690/4885HTT 213/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.