Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 2/20 | 0.35 |
| ▸ | TTR | P02766 | 2/20 | 0.33 |
| ▸ | ALB | P02768 | 2/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29813213 | 0.86 | ADRA1D (0.45) | VCAM1ADRA1DMAOAMAOB | |
| SCHEMBL26966869 | 0.86 | ADRA1D (0.45) | VCAM1ADRA1DMAOAMAOB | |
| SCHEMBL253203 | 0.79 | GLA (0.51) | GLACYP11B1CYP11B2FFAR1MEP1A | |
| SCHEMBL30646949 | 0.79 | GLA (0.51) | GLACYP11B1CYP11B2FFAR1MEP1A | |
| SCHEMBL2240175 | 0.76 | LOXL2 (0.54) | LOXL2CYP2A6HTTCYP11B1CYP11B2 | |
| SCHEMBL6740528 | 0.75 | TTR (0.41) | VCAM1TTRALBLOXL2CYP2A6 | |
| SCHEMBL2163202 | 0.74 | XDH (0.38) | VCAM1TTRALBLOXL2CYP2A6 | |
| SCHEMBL21275388 | 0.74 | KIF11 (0.33) | VCAM1FFAR1 | |
| SCHEMBL1338614 | 0.74 | TTR (0.33) | VCAM1TTRALBCYP2A6MEN1 | |
| SCHEMBL1542913 | 0.74 | LOXL2 (0.41) | VCAM1TTRALBLOXL2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4573077-A1 | APOL1 INHIBITORS AND METHODS OF USE | Maze Therapeutics, Inc. (US) | 2025-06-25 | — | — | EP | disclosed |
| WO-2024249252-A1 | METHODS OF USING APOL1 INHIBITORS | MAZE THERAPEUTICS, INC. (US) | 2024-12-05 | — | — | WO | disclosed |
| WO-2024040235-A1 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2024-02-22 | — | — | WO | disclosed |