SCHEMBL30748752

SCHEMBL30748752

CNc1nc(Cl)nc2c(Br)csc12

nearest known ligand 0.44

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
YTHDC1 Q96MU7 7/20 0.44
PRKCI P41743 9/20 0.41
XDH P47989 1/20 0.36
PDE2A O00408 1/20 0.35
YTHDF3 Q7Z739 2/20 0.33
YTHDF1 Q9BYJ9 2/20 0.33
YTHDF2 Q9Y5A9 2/20 0.33
POLB P06746 1/20 0.32
MAPT P10636 1/20 0.32
CACNA1B Q00975 1/20 0.32
APBA1 Q02410 1/20 0.32
HTT P42858 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19933189 0.86 YTHDC1 (0.44) YTHDC1PRKCIXDHPDE2AYTHDF3
SCHEMBL30677310 0.83 PRKCI (0.39) YTHDC1PRKCIPOLBMAPT
SCHEMBL2920664 0.80 PRKCI (0.48) PRKCI
SCHEMBL7679038 0.76 YTHDC1 (0.36) YTHDC1XDHPDE2AYTHDF3YTHDF1
SCHEMBL29999199 0.76 GPR35 (0.32) PRKCI
SCHEMBL1284962 0.76 GPR35 (0.32) PRKCI
SCHEMBL7684270 0.75 ALDH1A1 (0.44) PRKCIMAPTHTT
SCHEMBL1899418 0.74 EGFR (0.40) PRKCIMAPTHTT
SCHEMBL1899420 0.74 EGFR (0.40) PRKCIMAPTHTT
SCHEMBL1895629 0.73 PDE5A (0.52) PRKCI

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250304571-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF SUZHOU KEEN THERAPEUTICS CO., LTD. (CN) 2025-10-02 US disclosed
EP-4565588-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF Suzhou Keen Therapeutics Co., Ltd. (CN) 2025-06-11 EP disclosed
WO-2023241620-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF SUZHOU KEEN THERAPEUTICS CO., LTD. (CN) 2023-12-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250304571-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF VHL, BRCA1, TERT YTHDC1 2851/4885PRKCI 3526/4885XDH 404/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.