SCHEMBL30749074

SCHEMBL30749074

O=C1N(c2ccc(N3CCOCC3)cc2)c2nc(CO)nc(C(F)(F)F)c2C12CCCC2

nearest known ligand 0.35

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.35
SYK P43405 2/20 0.33
DGAT1 O75907 1/20 0.33
GAA P10253 1/20 0.33
GLA P06280 1/20 0.33
AKR1C3 P42330 1/20 0.33
STAT6 P42226 1/20 0.33
EBP Q15125 3/20 0.33
KCNH2 Q12809 2/20 0.33
MAPT P10636 2/20 0.33
PIK3C2B O00750 1/20 0.33
LMNA P02545 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30749110 0.85 MAPT (0.33) L3MBTL1SYKMAPT
SCHEMBL30748928 0.85 MAPT (0.34) L3MBTL1SYKAKR1C3MAPT
SCHEMBL30748855 0.81 SYK (0.39) SYKGAAMAPT
SCHEMBL30749021 0.77 CCNE1 (0.36) SYKSTAT6
SCHEMBL30749140 0.74 MAPT (0.39) L3MBTL1MAPTLMNA
SCHEMBL30748888 0.74 CCNE1 (0.39) SYKGAASTAT6MAPT
SCHEMBL30748754 0.74 XDH (0.36) L3MBTL1DGAT1GAAMAPT
SCHEMBL30748964 0.73 CCNE1 (0.37) SYKSTAT6MAPT
SCHEMBL31691226 0.72 TNKS (0.30)
SCHEMBL30748933 0.72 SYK (0.40) L3MBTL1SYKGAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250304571-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF SUZHOU KEEN THERAPEUTICS CO., LTD. (CN) 2025-10-02 US disclosed
EP-4565588-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF Suzhou Keen Therapeutics Co., Ltd. (CN) 2025-06-11 EP disclosed
WO-2023241620-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF SUZHOU KEEN THERAPEUTICS CO., LTD. (CN) 2023-12-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250304571-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF VHL, BRCA1, TERT L3MBTL1 517/4885SYK 2316/4885DGAT1 1487/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.