Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 6/20 | 0.47 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 2/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31496831 | 0.85 | PRMT5 (0.60) | PRMT5WDR77PARP1MAPTHSD17B10 | |
| SCHEMBL30753007 | 0.85 | PRMT5 (0.45) | PRMT5WDR77PARP1MAPTRECQL | |
| SCHEMBL29915228 | 0.81 | PRMT5 (0.49) | PRMT5WDR77PARP1MAPTHPGD | |
| SCHEMBL23087856 | 0.81 | PRMT5 (0.49) | PRMT5WDR77PARP1MAPTHPGD | |
| SCHEMBL27002267 | 0.72 | PRMT5 (0.64) | PRMT5WDR77PARP1MAPTRECQL | |
| SCHEMBL29915208 | 0.72 | PRMT5 (0.64) | PRMT5WDR77PARP1MAPTRECQL | |
| SCHEMBL23087658 | 0.72 | PRMT5 (0.64) | PRMT5WDR77PARP1MAPTRECQL | |
| SCHEMBL29735166 | 0.72 | PRMT5 (0.64) | PRMT5WDR77PARP1MAPTRECQL | |
| SCHEMBL29915065 | 0.70 | PRMT5 (0.61) | PRMT5WDR77PARP1 | |
| SCHEMBL27002364 | 0.70 | PRMT5 (0.61) | PRMT5WDR77PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119585261-A | PRMT5 inhibitor, preparation method and application thereof | 上海艾力斯医药科技股份有限公司 | 2025-03-07 | — | — | CN | disclosed |
| WO-2024027703-A1 | PRMT5 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海艾力斯医药科技股份有限公司 | 2024-02-08 | — | — | WO | disclosed |