Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KISS1R | Q969F8 | 2/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 10/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | CCKAR | P32238 | 6/20 | 0.39 |
| ▸ | CCKBR | P32239 | 6/20 | 0.39 |
| ▸ | NPY4R | P50391 | 2/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.38 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.38 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31754252 | 0.92 | KISS1R (0.45) | KISS1ROPRD1OPRM1CCKARCCKBR | |
| SCHEMBL30759452 | 0.86 | ERAP2 (0.49) | OPRD1OPRM1NPY4RNPY1RERAP2 | |
| SCHEMBL30759431 | 0.82 | KLKB1 (0.36) | KISS1ROPRD1CCKARCCKBRERAP2 | |
| SCHEMBL30759400 | 0.79 | SLC7A5 (0.40) | OPRD1OPRM1ERAP2LNPEPERAP1 | |
| SCHEMBL30759465 | 0.78 | LMNA (0.37) | OPRD1OPRM1ERAP2LNPEPERAP1 | |
| SCHEMBL31072486 | 0.77 | KISS1R (0.50) | KISS1ROPRD1OPRM1CCKARCCKBR | |
| SCHEMBL30759423 | 0.77 | GRIA1 (0.42) | KISS1ROPRM1LNPEP | |
| SCHEMBL30759435 | 0.76 | ERAP2 (0.53) | OPRD1OPRM1NPY4RNPY1RERAP2 | |
| SCHEMBL30759455 | 0.73 | CTSK (0.42) | KISS1ROPRD1OPRM1REN | |
| SCHEMBL30759453 | 0.73 | SLC7A5 (0.42) | OPRD1ERAP2LNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260001914-A1 | MACROCYCLIC PEPTIDES TARGETING KRAS | MERCK SHARP & DOHME LLC (US) | 2026-01-01 | — | — | US | disclosed |
| EP-4558513-A1 | MACROCYCLIC PEPTIDES TARGETING KRAS | Merck Sharp & Dohme LLC (US) | 2025-05-28 | — | — | EP | disclosed |
| WO-2024020159-A1 | MACROCYCLIC PEPTIDES TARGETING KRAS | MERCK SHARP & DOHME LLC (US) | 2024-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260001914-A1 | MACROCYCLIC PEPTIDES TARGETING KRAS | KRAS, NRAS, HRAS | KISS1R 2731/4885OPRD1 2249/4885OPRM1 2520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.