Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 6/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | BCR | P11274 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.33 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.33 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27262456 | 1.00 | NAMPT (0.37) | NAMPTPIK3C3KDM1AHPGDTBK1 | |
| SCHEMBL30765285 | 0.87 | GLRA1 (0.39) | NAMPT | |
| SCHEMBL30765255 | 0.87 | GLRA1 (0.39) | NAMPT | |
| SCHEMBL30765202 | 0.87 | GLRA1 (0.39) | NAMPT | |
| SCHEMBL30765178 | 0.86 | NPC1 (0.43) | NAMPTHPGDJAK2 | |
| SCHEMBL30765379 | 0.86 | NPC1 (0.43) | NAMPTHPGDJAK2 | |
| SCHEMBL27263347 | 0.86 | NPC1 (0.43) | NAMPTHPGDJAK2 | |
| SCHEMBL27263346 | 0.86 | NPC1 (0.43) | NAMPTHPGDJAK2 | |
| SCHEMBL30765407 | 0.86 | TGFBR1 (0.42) | HPGDHDAC4JAK2 | |
| SCHEMBL27262365 | 0.86 | TGFBR1 (0.42) | HPGDHDAC4JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024033280-A1 | FUROPYRIDIN AND FUROPYRIMIDIN, INHIBITORS OF PI4K, FOR USE IN THE TREATMENT OF PARASITE INFECTION AND MALARIA | MERCK PATENT GMBH (DE) | 2024-02-15 | — | — | WO | disclosed |