Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | JAK1 | P23458 | 3/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.41 |
| ▸ | CDK9 | P50750 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.38 |
| ▸ | RAF1 | P04049 | 3/20 | 0.38 |
| ▸ | BRAF | P15056 | 3/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | MLYCD | O95822 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27262365 | 1.00 | TGFBR1 (0.42) | TGFBR1KCNH2JAK2JAK1TYK2 | |
| SCHEMBL30765255 | 0.89 | GLRA1 (0.39) | TGFBR1RAF1BRAF | |
| SCHEMBL30765285 | 0.89 | GLRA1 (0.39) | TGFBR1RAF1BRAF | |
| SCHEMBL30765202 | 0.89 | GLRA1 (0.39) | TGFBR1RAF1BRAF | |
| SCHEMBL30765189 | 0.89 | ABL1 (0.35) | KCNH2CCNT1CDK9HPGDRAF1 | |
| SCHEMBL27262537 | 0.89 | ABL1 (0.35) | KCNH2CCNT1CDK9HPGDRAF1 | |
| SCHEMBL30765225 | 0.88 | CA9 (0.40) | JAK2JAK1TYK2JAK3MTOR | |
| SCHEMBL27263074 | 0.88 | CA9 (0.40) | JAK2JAK1TYK2JAK3MTOR | |
| SCHEMBL30765367 | 0.88 | CCNT1 (0.40) | TGFBR1KCNH2CCNT1CDK9HPGD | |
| SCHEMBL30765360 | 0.87 | PIK3C3 (0.34) | CCNT1CDK9RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024033280-A1 | FUROPYRIDIN AND FUROPYRIMIDIN, INHIBITORS OF PI4K, FOR USE IN THE TREATMENT OF PARASITE INFECTION AND MALARIA | MERCK PATENT GMBH (DE) | 2024-02-15 | — | — | WO | disclosed |