Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 5/20 | 0.33 |
| ▸ | BRAF | P15056 | 5/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | CBLB | Q13191 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | VNN1 | O95497 | 1/20 | 0.32 |
| ▸ | BTD | P43251 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30765184 | 0.90 | CCNC (0.35) | PIK3C3LRRK2RAF1BRAFTTK | |
| SCHEMBL27262365 | 0.87 | TGFBR1 (0.42) | RAF1BRAFCCNT1CDK9 | |
| SCHEMBL30765407 | 0.87 | TGFBR1 (0.42) | RAF1BRAFCCNT1CDK9 | |
| SCHEMBL27262537 | 0.84 | ABL1 (0.35) | RAF1BRAFGABRA5NAMPTCCNT1 | |
| SCHEMBL30765189 | 0.84 | ABL1 (0.35) | RAF1BRAFGABRA5NAMPTCCNT1 | |
| SCHEMBL30765284 | 0.84 | LRRK2 (0.34) | PIK3C3LRRK2EGLN1RAF1BRAF | |
| SCHEMBL27263165 | 0.84 | PDE4B (0.34) | RAF1BRAFPDE4BNAMPT | |
| SCHEMBL30765178 | 0.83 | NPC1 (0.43) | NAMPT | |
| SCHEMBL30765379 | 0.83 | NPC1 (0.43) | NAMPT | |
| SCHEMBL27263347 | 0.83 | NPC1 (0.43) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024033280-A1 | FUROPYRIDIN AND FUROPYRIMIDIN, INHIBITORS OF PI4K, FOR USE IN THE TREATMENT OF PARASITE INFECTION AND MALARIA | MERCK PATENT GMBH (DE) | 2024-02-15 | — | — | WO | disclosed |