4-Hydroxynon-2-Enal

4-Hydroxynon-2-Enal

SCHEMBL30767210

CCCCCC(O)/C=C\C=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
GAPDH P04406 2/20 1.00
TRPA1 O75762 2/20 1.00
DDAH1 O94760 1/20 1.00
MAPT P10636 1/20 1.00
ACHE P22303 1/20 0.55
BACE1 P56817 1/20 0.55
PPARG P37231 2/20 0.53
FPR2 P25090 2/20 0.53
GPR132 Q9UNW8 1/20 0.53
NFKB1 P19838 1/20 0.53
NFKB2 Q00653 1/20 0.53
RELA Q04206 1/20 0.53
LTB4R2 Q9NPC1 1/20 0.50
OXER1 Q8TDS5 1/20 0.48
FAAH O00519 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
4-Hydroxynon-2-Enal SCHEMBL3921 1.00 GAPDH (1.00) GAPDHTRPA1DDAH1MAPTACHE
4-Hydroxynon-2-Enal SCHEMBL2890600 1.00 GAPDH (1.00) GAPDHTRPA1DDAH1MAPTACHE
4-Hydroxynon-2-Enal SCHEMBL3920 1.00 GAPDH (1.00) GAPDHTRPA1DDAH1MAPTACHE
4-Hydroxynon-2-Enal SCHEMBL2890601 1.00 GAPDH (1.00) GAPDHTRPA1DDAH1MAPTACHE
SCHEMBL8304538 0.98 GAPDH (0.96) GAPDHTRPA1DDAH1MAPTACHE
SCHEMBL8309540 0.98 GAPDH (0.96) GAPDHTRPA1DDAH1MAPTACHE
4-Hydroxynon-2-Enal SCHEMBL2267834 0.98 GAPDH (0.96) GAPDHTRPA1DDAH1MAPTACHE
SCHEMBL28058254 0.98 GAPDH (0.96) GAPDHTRPA1DDAH1MAPTACHE
SCHEMBL8304537 0.98 GAPDH (0.96) GAPDHTRPA1DDAH1MAPTACHE
SCHEMBL8309537 0.98 GAPDH (0.96) GAPDHTRPA1DDAH1MAPTACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024215861-A2 NISIN-BASED FORMULATIONS FOR ORAL AND SYSTEMIC CONDITIONS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-10-17 WO disclosed
WO-2024031149-A1 METHODS FOR THE DETECTION OF MYELOPEROXIDASE THE UNIVERSITY OF SYDNEY (AU) 2024-02-15 WO disclosed