4-Hydroxynon-2-Enal

4-Hydroxynon-2-Enal

SCHEMBL3920

CCCCCC(O)/C=C/C=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
GAPDH P04406 2/20 1.00
TRPA1 O75762 2/20 1.00
DDAH1 O94760 1/20 1.00
MAPT P10636 1/20 1.00
ACHE P22303 1/20 0.55
BACE1 P56817 1/20 0.55
PPARG P37231 2/20 0.53
FPR2 P25090 2/20 0.53
GPR132 Q9UNW8 1/20 0.53
NFKB1 P19838 1/20 0.53
NFKB2 Q00653 1/20 0.53
RELA Q04206 1/20 0.53
LTB4R2 Q9NPC1 1/20 0.50
OXER1 Q8TDS5 1/20 0.48
FAAH O00519 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
4-Hydroxynon-2-Enal SCHEMBL3921 1.00 GAPDH (1.00) GAPDHTRPA1DDAH1MAPTACHE
4-Hydroxynon-2-Enal SCHEMBL2890600 1.00 GAPDH (1.00) GAPDHTRPA1DDAH1MAPTACHE
4-Hydroxynon-2-Enal SCHEMBL30767210 1.00 GAPDH (1.00) GAPDHTRPA1DDAH1MAPTACHE
4-Hydroxynon-2-Enal SCHEMBL2890601 1.00 GAPDH (1.00) GAPDHTRPA1DDAH1MAPTACHE
SCHEMBL8304538 0.98 GAPDH (0.96) GAPDHTRPA1DDAH1MAPTACHE
SCHEMBL8309540 0.98 GAPDH (0.96) GAPDHTRPA1DDAH1MAPTACHE
4-Hydroxynon-2-Enal SCHEMBL2267834 0.98 GAPDH (0.96) GAPDHTRPA1DDAH1MAPTACHE
SCHEMBL28058254 0.98 GAPDH (0.96) GAPDHTRPA1DDAH1MAPTACHE
SCHEMBL8304537 0.98 GAPDH (0.96) GAPDHTRPA1DDAH1MAPTACHE
SCHEMBL8309537 0.98 GAPDH (0.96) GAPDHTRPA1DDAH1MAPTACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 7405 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026104986-A1 NEW MOLECULES AND THEIR USE IN THE TREATMENT OF PATHOLOGIES RELATED TO OXIDATIVE STRESS FIDIA FARMACEUTICI S.P.A. (IT) 2026-05-21 WO claimed
CN-122032334-A Composite oxygenation membrane with active aldehyde removal function, and preparation method and application thereof 大连理工大学 2026-05-15 CN claimed
EP-4363043-B1 COMPOSITIONS FOR USE IN METHODS FOR INCREASING CANCER CELL SENSITIVITY TO ALTERNATING ELECTRIC FIELDS NOVOCURE GMBH (CH) 2026-04-22 EP claimed
US-12594421-B2 Compositions and methods for increasing cancer cell sensitivity to alternating electric fields NOVOCURE GMBH (CH) 2026-04-07 US claimed
US-12582704-B2 Food composition for improving behavioral and motor function containing aldehyde dehydrogenase for reducing aldehydes produced by oxidation of alcohol PICOENTECH Co., LTD. (KR) 2026-03-24 US claimed
EP-4684214-A2 BIOMARKERS OF AMYOTROPHIC LATERAL SCLEROSIS AND USES THEREOF The Methodist Hospital (US) 2026-01-28 EP claimed
EP-4683527-A1 VAPORIZABLE ALKALOID COMPOSITIONS AND METHODS OF USE THEREOF Ready Mix Naturals, LLC (US) 2026-01-28 EP claimed
US-12517110-B2 Noninvasive detection of cancer originating in tissue outside the lung using exhaled breath UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) 2026-01-06 US claimed
US-12497381-B2 Vaporizable alkaloid compositions and methods of use thereof Ready Mix Naturals, LLC (US) 2025-12-16 US claimed
US-12478091-B2 Vaporizable alkaloid compositions and methods of use thereof Ready Mix Naturals, LLC (US) 2025-11-25 US claimed
EP-1189937-A1 PURIFIED ANTIGEN FOR ALZHEIMER'S DISEASE, AND METHODS OF OBTAINING AND USING SAME MOLECULAR GERIATRICS CORPORATION (US) 2002-03-27 EP claimed
US-20020016284-A1 Olfactory neuron cultures and method of making and using the same PANACEA PHARMACEUTICALS, INC. 2002-02-07 US claimed
WO-2002004029-A1 OLFACTORY NEURON CULTURES AND METHOD OF MAKING AND USING THE SAME PANACEA PHARMACEUTICALS, INC. (US) 2002-01-17 WO claimed
US-20020002270-A1 PURIFIED ANTIGEN FOR ALZHEIMER'S DISEASE, AND METHODS OF OBTAINING AND USING SAME MOLECULAR GERIATRICS CORPORATION 2002-01-03 US claimed
WO-2001068119-A1 ATHEROSCLEROSIS VACCINE FORSKARPATENT I SYD AB (SE) 2001-09-20 WO claimed
WO-2000078807-A1 PURIFIED ANTIGEN FOR ALZHEIMER'S DISEASE, AND METHODS OF OBTAINING AND USING SAME MOLECULAR GERIATRICS CORPORATION (US) 2000-12-28 WO claimed
EP-0968230-A1 OXIDIZED FRAGMENTS OF APOLIPOPROTEIN B AND THEIR USE UNIVERSITY OF LEICESTER (GB) 2000-01-05 EP claimed
WO-1999004268-A9 LIPID HYDROPEROXIDES TO DETECT BRAIN INJURY GEN HOSPITAL CORP (US) 1999-04-22 WO claimed
WO-1999004268-A1 LIPID HYDROPEROXIDES TO DETECT BRAIN INJURY THE GENERAL HOSPITAL CORPORATION (US) 1999-01-28 WO claimed
WO-1998042751-A1 OXIDISED FRAGMENTS OF APOLIPOPROTEIN B AND THEIR USE UNIVERSITY OF LEICESTER (GB) 1998-10-01 WO claimed