4-Hydroxynon-2-Enal

4-Hydroxynon-2-Enal

SCHEMBL3921

CCCCCC(O)C=CC=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ GAPDH P04406 2/20 1.00
▸ TRPA1 O75762 2/20 1.00
▸ DDAH1 O94760 1/20 1.00
▸ MAPT P10636 1/20 1.00
▸ ACHE P22303 1/20 0.55
▸ BACE1 P56817 1/20 0.55
▸ PPARG P37231 2/20 0.53
▸ FPR2 P25090 2/20 0.53
▸ GPR132 Q9UNW8 1/20 0.53
▸ NFKB1 P19838 1/20 0.53
▸ NFKB2 Q00653 1/20 0.53
▸ RELA Q04206 1/20 0.53
▸ LTB4R2 Q9NPC1 1/20 0.50
▸ OXER1 Q8TDS5 1/20 0.48
▸ FAAH O00519 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
4-Hydroxynon-2-Enal SCHEMBL30767210 1.00 GAPDH (1.00) GAPDHTRPA1DDAH1MAPTACHE
4-Hydroxynon-2-Enal SCHEMBL2890601 1.00 GAPDH (1.00) GAPDHTRPA1DDAH1MAPTACHE
4-Hydroxynon-2-Enal SCHEMBL3920 1.00 GAPDH (1.00) GAPDHTRPA1DDAH1MAPTACHE
4-Hydroxynon-2-Enal SCHEMBL2890600 1.00 GAPDH (1.00) GAPDHTRPA1DDAH1MAPTACHE
SCHEMBL8309537 0.98 GAPDH (0.96) GAPDHTRPA1DDAH1MAPTACHE
4-Hydroxynon-2-Enal SCHEMBL2267834 0.98 GAPDH (0.96) GAPDHTRPA1DDAH1MAPTACHE
SCHEMBL8309540 0.98 GAPDH (0.96) GAPDHTRPA1DDAH1MAPTACHE
SCHEMBL28058254 0.98 GAPDH (0.96) GAPDHTRPA1DDAH1MAPTACHE
SCHEMBL8304537 0.98 GAPDH (0.96) GAPDHTRPA1DDAH1MAPTACHE
SCHEMBL8304538 0.98 GAPDH (0.96) GAPDHTRPA1DDAH1MAPTACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 7250 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026104986-A1 NEW MOLECULES AND THEIR USE IN THE TREATMENT OF PATHOLOGIES RELATED TO OXIDATIVE STRESS FIDIA FARMACEUTICI S.P.A. (IT) 2026-05-21 — — WO claimed
CN-122032334-A Composite oxygenation membrane with active aldehyde removal function, and preparation method and application thereof 大连理工大学 2026-05-15 — — CN claimed
EP-4363043-B1 COMPOSITIONS FOR USE IN METHODS FOR INCREASING CANCER CELL SENSITIVITY TO ALTERNATING ELECTRIC FIELDS NOVOCURE GMBH (CH) 2026-04-22 — — EP claimed
US-12582704-B2 Food composition for improving behavioral and motor function containing aldehyde dehydrogenase for reducing aldehydes produced by oxidation of alcohol PICOENTECH Co., LTD. (KR) 2026-03-24 — — US claimed
EP-4684214-A2 BIOMARKERS OF AMYOTROPHIC LATERAL SCLEROSIS AND USES THEREOF The Methodist Hospital (US) 2026-01-28 — — EP claimed
EP-4683527-A1 VAPORIZABLE ALKALOID COMPOSITIONS AND METHODS OF USE THEREOF Ready Mix Naturals, LLC (US) 2026-01-28 — — EP claimed
US-12517110-B2 Noninvasive detection of cancer originating in tissue outside the lung using exhaled breath UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) 2026-01-06 — — US claimed
US-12497381-B2 Vaporizable alkaloid compositions and methods of use thereof Ready Mix Naturals, LLC (US) 2025-12-16 — — US claimed
US-12478091-B2 Vaporizable alkaloid compositions and methods of use thereof Ready Mix Naturals, LLC (US) 2025-11-25 — — US claimed
US-12473342-B2 Chimeric antigen receptor T regulatory cells for the treatment of atherosclerosis THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2025-11-18 — — US claimed
WO-2002004029-A1 OLFACTORY NEURON CULTURES AND METHOD OF MAKING AND USING THE SAME PANACEA PHARMACEUTICALS, INC. (US) 2002-01-17 — — WO claimed
US-20020002270-A1 PURIFIED ANTIGEN FOR ALZHEIMER'S DISEASE, AND METHODS OF OBTAINING AND USING SAME MOLECULAR GERIATRICS CORPORATION 2002-01-03 — — US claimed
WO-2001068119-A1 ATHEROSCLEROSIS VACCINE FORSKARPATENT I SYD AB (SE) 2001-09-20 — — WO claimed
WO-2000078807-A1 PURIFIED ANTIGEN FOR ALZHEIMER'S DISEASE, AND METHODS OF OBTAINING AND USING SAME MOLECULAR GERIATRICS CORPORATION (US) 2000-12-28 — — WO claimed
EP-0968230-A1 OXIDIZED FRAGMENTS OF APOLIPOPROTEIN B AND THEIR USE UNIVERSITY OF LEICESTER (GB) 2000-01-05 — — EP claimed
WO-1999004268-A9 LIPID HYDROPEROXIDES TO DETECT BRAIN INJURY GEN HOSPITAL CORP (US) 1999-04-22 — — WO claimed
WO-1999004268-A1 LIPID HYDROPEROXIDES TO DETECT BRAIN INJURY THE GENERAL HOSPITAL CORPORATION (US) 1999-01-28 — — WO claimed
WO-1998042751-A1 OXIDISED FRAGMENTS OF APOLIPOPROTEIN B AND THEIR USE UNIVERSITY OF LEICESTER (GB) 1998-10-01 — — WO claimed
EP-0833901-A1 METHOD FOR IDENTIFYING ALZHEIMER'S DISEASE THERAPEUTICS USING TRANSGENIC ANIMAL MODELS Athena Neurosciences, Inc. (US) 1998-04-08 — — EP claimed
WO-1996040896-A1 METHOD FOR IDENTIFYING ALZHEIMER'S DISEASE THERAPEUTICS USING TRANSGENIC ANIMAL MODELS ATHENA NEUROSCIENCES, INC. (US) 1996-12-19 — — WO claimed
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