Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9954720 | 0.75 | GPR35 (0.40) | ERN1EPHX2CYP1A2GRIN2DGRIN3B | |
| SCHEMBL21048201 | 0.70 | ALDH1A1 (0.46) | EPHX2CYP1A2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL30770947 | 0.70 | KMO (0.44) | ERN1CYP1A2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL9382154 | 0.70 | GRIN2D (0.38) | EPHX2CYP1A2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL25260021 | 0.69 | KMO (0.46) | CYP1A2GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL30483748 | 0.66 | KMO (0.46) | CYP1A2GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL25289763 | 0.66 | KMO (0.46) | CYP1A2GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL31620373 | 0.66 | KDM4E (0.34) | ERN1CYP1A2CYP3A4MAPTTSHR | |
| SCHEMBL2482652 | 0.65 | EPHX2 (0.49) | EPHX2CYP1A2LMNACYP3A4MAPT | |
| SCHEMBL30771217 | 0.65 | MAPT (0.44) | ERN1CYP1A2GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4561563-A2 | TRICYCLIC ARYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF | Ensem Therapeutics, Inc. (US) | 2025-06-04 | — | — | EP | disclosed |
| CN-119947718-A | Tricyclic aryl derivatives, and compositions and methods thereof | 昂胜医疗科技公司 | 2025-05-06 | — | — | CN | disclosed |
| WO-2024026129-A2 | TRICYCLIC ARYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF | ENSEM THERAPEUTICS, INC. (US) | 2024-02-01 | — | — | WO | disclosed |