SCHEMBL3077135

SCHEMBL3077135

NCC#Cc1cn(C2CC(O)C(OP(=O)(O)O)O2)c(=O)[nH]c1=O

nearest known ligand 0.64

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ TK1 P04183 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2622504 0.84 TK1 (0.47) TK1
Phosphoric Acid SCHEMBL7220598 0.84 TK1 (0.59) TK1
SCHEMBL2231702 0.81 TK1 (0.64) TK1
SCHEMBL13669402 0.81 TK1 (0.64) TK1
SCHEMBL5532799 0.81 TK1 (0.64) TK1
SCHEMBL13258664 0.81 TYMS (0.55) —
SCHEMBL13644730 0.81 TK1 (0.53) TK1
SCHEMBL12133411 0.81 TK1 (0.45) TK1
SCHEMBL20074268 0.80 POLB (0.55) —
SCHEMBL304477 0.80 POLB (0.55) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3848380-A1 LABELLED NUCLEOTIDES Illumina Cambridge Limited (GB) 2021-07-14 — — EP disclosed
US-11028116-B2 Labelled nucleotides ILLUMINA CAMBRIDGE LIMITED (GB) 2021-06-08 — — US disclosed
US-11028115-B2 Labelled nucleotides ILLUMINA CAMBRIDGE LIMITED (GB) 2021-06-08 — — US disclosed
US-11008359-B2 Labelled nucleotides ILLUMINA CAMBRIDGE LIMITED (GB) 2021-05-18 — — US disclosed
US-10995111-B2 Labelled nucleotides ILLUMINA CAMBRIDGE LIMITED (GB) 2021-05-04 — — US disclosed
US-20210047357-A1 LABELLED NUCLEOTIDES ILLUMINA CAMBRIDGE LIMITED (GB) 2021-02-18 — — US disclosed
EP-3438116-B1 LABELLED NUCLEOTIDES ILLUMINA CAMBRIDGE LTD (GB) 2021-02-17 — — EP disclosed
US-20210009622-A1 LABELLED NUCLEOTIDES SOLEXA LIMITED (GB) 2021-01-14 — — US disclosed
US-20210009623-A1 LABELLED NUCLEOTIDES SOLEXA LIMITED (GB) 2021-01-14 — — US disclosed
US-20200325167-A1 LABELLED NUCLEOTIDES SOLEXA LIMITED (GB) 2020-10-15 — — US disclosed
US-20140141414-A1 LABELLED NUCLEOTIDES ILLUMINA CAMBRIDGE LIMITED (GB) 2014-05-22 — — US disclosed
US-20120156671-A1 LABELLED NUCLEOTIDES ILLUMINA CAMBRIDGE LIMITED (GB) 2012-06-21 — — US disclosed
US-8084590-B2 Labelled nucleotides ILLUMINA CAMBRIDGE LIMITED (GB) 2011-12-27 — — US disclosed
US-20100311178-A1 Labelled nucleotides ILLUMINA CAMBRIDGE LIMITED 2010-12-09 — — US disclosed
US-7795424-B2 Labelled nucleotides ILLUMINA CAMBRIDGE LIMITED (GB) 2010-09-14 — — US disclosed
EP-2119722-A1 Labelled nucleotides Illumina Cambridge Limited (GB) 2009-11-18 — — EP disclosed
EP-1560838-B1 LABELLED NUCLEOTIDES ILLUMINA CAMBRIDGE LTD (GB) 2009-05-13 — — EP disclosed
US-20090062145-A1 Labelled nucleotides ILLUMINA CAMBRIDGE LIMITED (GB) 2009-03-05 — — US disclosed
US-7414116-B2 certain linkers connecting nucleotide bases to detachable labels (fluorophores) are cleaved using water soluble phosphines transition metal catalysts; sequencing; used in nick translation, random primer labeling, end-labeling (terminal deoxynucleotidyltransferase), reverse transcription, amplification ILLUMINA CAMBRIDGE LIMITED (GB) 2008-08-19 — — US disclosed
US-20060160081-A1 certain linkers connecting nucleotide bases to detachable labels (fluorophores) are cleaved using water soluble phosphines transition metal catalysts; sequencing; used in nick translation, random primer labeling, end-labeling (terminal deoxynucleotidyltransferase), reverse transcription, amplification ILLUMINA CAMBRIDGE LIMITED (GB) 2006-07-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200325167-A1 LABELLED NUCLEOTIDES NUDT1, DUT, NT5C2 TK1 22/4885
US-20060160081-A1 certain linkers connecting nucleotide bases to detachable labels (fluorophores) are cleaved using water soluble phosphines transition metal catalysts; sequencing; used in nick translation, random primer labeling, end-labeling (terminal deoxynucleotidyltransferase), reverse transcription, amplification RNGTT, DNTT, POLQ TK1 20/4885
US-20210009623-A1 LABELLED NUCLEOTIDES NUDT1, DUT, NT5C2 TK1 22/4885
US-20210009622-A1 LABELLED NUCLEOTIDES NUDT1, DUT, NT5C2 TK1 22/4885
US-11008359-B2 Labelled nucleotides NUDT1, DUT, NT5C2 TK1 22/4885
US-20100311178-A1 Labelled nucleotides NUDT1, DUT, NT5C2 TK1 22/4885
US-20210047357-A1 LABELLED NUCLEOTIDES NUDT1, DUT, NT5C2 TK1 22/4885
US-10995111-B2 Labelled nucleotides NUDT1, DUT, NT5C2 TK1 22/4885
US-11028116-B2 Labelled nucleotides NUDT1, DUT, NT5C2 TK1 22/4885
US-11028115-B2 Labelled nucleotides NUDT1, DUT, NT5C2 TK1 22/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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