Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 11/20 | 0.40 |
| ▸ | NOS3 | P29474 | 10/20 | 0.40 |
| ▸ | NOS1 | P29475 | 10/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30774828 | 0.89 | NOS2 (0.36) | NOS2NOS3NOS1HTTALDH1A1 | |
| SCHEMBL30774788 | 0.88 | ALDH1A1 (0.43) | NOS2NOS3NOS1HTTALDH1A1 | |
| SCHEMBL30774893 | 0.88 | NOS2 (0.38) | NOS2NOS3NOS1HTTALDH1A1 | |
| SCHEMBL30774803 | 0.86 | PRMT1 (0.36) | NOS2NOS3NOS1ARHTT | |
| SCHEMBL30774815 | 0.86 | ALDH1A1 (0.42) | NOS2NOS3NOS1ARLMNA | |
| SCHEMBL31448690 | 0.81 | ALDH1A1 (0.44) | NOS2NOS3NOS1CYP2D6HTT | |
| SCHEMBL30774810 | 0.81 | ALDH1A1 (0.44) | NOS2NOS3NOS1CYP2D6HTT | |
| SCHEMBL30774771 | 0.80 | ALDH1A1 (0.35) | NOS2NOS3NOS1SLC6A4ALDH1A1 | |
| SCHEMBL30774819 | 0.80 | ALDH1A1 (0.41) | ABCB11ADORA3ARCYP2D6SLC6A2 | |
| SCHEMBL30774865 | 0.79 | PRMT1 (0.36) | LMNAALDH1A1MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260049068-A1 | Substituted Tetrazolyl Compounds Useful as T Cell Activators | BRISTOL MYERS SQUIBB CO (US) | 2026-02-19 | — | — | US | claimed |
| CN-119654312-A | Substituted tetrazolyl compounds useful as T cell activators | 百时美施贵宝公司 | 2025-03-18 | — | — | CN | claimed |
| US-20260049068-A1 | Substituted Tetrazolyl Compounds Useful as T Cell Activators | BRISTOL MYERS SQUIBB CO (US) | 2026-02-19 | — | — | US | disclosed |
| EP-4568950-A1 | SUBSTITUTED TETRAZOLYL COMPOUNDS USEFUL AS T CELL ACTIVATORS | Bristol-Myers Squibb Company (US) | 2025-06-18 | — | — | EP | disclosed |
| CN-119654312-A | Substituted tetrazolyl compounds useful as T cell activators | 百时美施贵宝公司 | 2025-03-18 | — | — | CN | disclosed |
| WO-2024036100-A1 | SUBSTITUTED TETRAZOLYL COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260049068-A1 | Substituted Tetrazolyl Compounds Useful as T Cell Activators | DGKZ, DGKA, DGKG | NOS2 3835/4885NOS3 3443/4885NOS1 3288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.