SCHEMBL30775975

SCHEMBL30775975

CC(C)(C)OC(=O)N1CC2(CC(Cn3ccc(Br)cc3=O)C2)C1

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 1/20 0.38
RORC P51449 2/20 0.37
GPR119 Q8TDV5 5/20 0.37
FPR2 P25090 1/20 0.36
EHMT2 Q96KQ7 1/20 0.36
OXTR P30559 1/20 0.36
AVPR1A P37288 1/20 0.36
USP30 Q70CQ3 1/20 0.36
GPR183 P32249 1/20 0.36
KRAS P01116 1/20 0.36
PARP1 P09874 1/20 0.35
NAMPT P43490 3/20 0.35
BACE1 P56817 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31108119 0.85 USP30 (0.43) RORCFPR2USP30KRASNAMPT
SCHEMBL30410253 0.85 ABHD6 (0.42) RORCGPR119EHMT2OXTRAVPR1A
SCHEMBL30775971 0.84 GPR119 (0.36) RORCGPR119EHMT2OXTRAVPR1A
SCHEMBL31108104 0.84 FPR2 (0.51) GPR119FPR2BACE1
SCHEMBL30775963 0.82 GPR119 (0.36) RORCGPR119EHMT2OXTRAVPR1A
SCHEMBL31108111 0.82 IDO1 (0.46) GPR119FPR2USP30
SCHEMBL3660874 0.80 FEN1 (0.48) FPR2USP30BACE1
SCHEMBL29497363 0.78 KRAS (0.36) RORCGPR119EHMT2OXTRAVPR1A
SCHEMBL26631496 0.78 KRAS (0.36) RORCGPR119EHMT2OXTRAVPR1A
SCHEMBL25326356 0.76 RORC (0.41) RORCGPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4568972-A1 NEW HETEROCYCLIC COMPOUNDS F. Hoffmann-La Roche AG (CH) 2025-06-18 EP disclosed
CN-119654326-A Novel heterocyclic compounds 豪夫迈·罗氏有限公司 2025-03-18 CN disclosed
WO-2024033277-A1 NEW HETEROCYCLIC COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2024-02-15 WO disclosed