Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL186794 | 0.81 | CA1 (0.64) | CA1CA2ALDH1A1KMT2AGSK3B | |
| Methylene Chloride SCHEMBL29223376 | 0.80 | ALDH1A1 (0.52) | CA1CA2ALDH1A1GSK3BMAPT | |
| SCHEMBL7132233 | 0.78 | HDAC1 (0.47) | CA1CA2ALDH1A1KMT2APOLB | |
| SCHEMBL1290930 | 0.78 | KMT2A (0.58) | CA1CA2ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL3962189 | 0.77 | CA1 (0.43) | CA1CA2ALDH1A1KMT2APOLB | |
| SCHEMBL68148 | 0.77 | ALDH1A1 (0.59) | CA1CA2ALDH1A1MAPTCES2 | |
| SCHEMBL20587670 | 0.77 | ALDH1A1 (0.59) | CA1CA2ALDH1A1MAPTCES2 | |
| SCHEMBL13138677 | 0.77 | KMT2A (0.41) | CA1CA2ALDH1A1KMT2AMAPT | |
| SCHEMBL91167 | 0.76 | PRSS1 (0.48) | CA1CA2ALDH1A1KMT2ARAB9A | |
| SCHEMBL18892653 | 0.74 | ALDH1A1 (0.43) | CA1CA2ALDH1A1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130121963-A1 | N-PHENYL-2-PYRIMIDINEAMINE DERIVATIVES | CONCERT PHARMACEUTICALS INC. (US) | 2013-05-16 | — | — | US | disclosed |
| US-20100221221-A1 | N-PHENYL-2-PYRIMIDINEAMINE DERIVATIVES | CONCERT PHARMACEUTICALS INC. (US) | 2010-09-02 | — | — | US | disclosed |
| WO-2010019557-A1 | N-PHENYL-2-PYRIMIDINEAMINE DERIVATIVES | CONCERT PHARMACEUTICALS INC. (US) | 2010-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130121963-A1 | N-PHENYL-2-PYRIMIDINEAMINE DERIVATIVES | NME2, NME1, ABL1 | CA1 4884/4885CA2 4403/4885ALDH1A1 3768/4885 |
| US-20100221221-A1 | N-PHENYL-2-PYRIMIDINEAMINE DERIVATIVES | NME2, NME1, ABL1 | CA1 4884/4885CA2 4403/4885ALDH1A1 3768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.