Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27265020 | 1.00 | RORC (0.49) | RORCLMNAMAOAHDAC1HDAC2 | |
| SCHEMBL27265046 | 0.87 | RORC (0.48) | RORCAAK1POLBALDH1A1GAA | |
| SCHEMBL10777152 | 0.83 | LMNA (0.50) | RORCLMNAMAOAHDAC1HDAC2 | |
| SCHEMBL11859469 | 0.82 | RORC (0.52) | RORCLMNAMAOAHDAC1HDAC2 | |
| SCHEMBL16774311 | 0.80 | APEX1 (0.57) | RORCLMNAMAOAHDAC1HDAC2 | |
| SCHEMBL4851453 | 0.80 | RORC (0.54) | RORCALDH1A1GAA | |
| SCHEMBL18025366 | 0.79 | CYP17A1 (0.47) | LMNAPOLBMAPKAPK2MAP4K4 | |
| SCHEMBL16303890 | 0.77 | EPHX1 (0.58) | LMNAPOLBALDH1A1GAAHTT | |
| SCHEMBL11893942 | 0.76 | EGFR (0.58) | — | |
| SCHEMBL17050474 | 0.75 | ALDH1A1 (0.54) | RORCAAK1POLBALDH1A1MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024030651-A1 | GPX4 INHIBITORS AND USE THEREOF | SONATA THERAPEUTICS, INC. (US) | 2024-02-08 | — | — | WO | disclosed |