Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GOT1 | P17174 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29442588 | 1.00 | GOT1 (0.46) | GOT1KDM4ELMNATP53NPC1 | |
| SCHEMBL1456807 | 1.00 | GOT1 (0.46) | GOT1KDM4ELMNATP53NPC1 | |
| SCHEMBL869236 | 0.89 | GOT1 (0.39) | GOT1KDM4ELMNATP53NPC1 | |
| SCHEMBL30176742 | 0.89 | GOT1 (0.39) | GOT1KDM4ELMNATP53NPC1 | |
| SCHEMBL3749780 | 0.89 | KDM4E (0.48) | GOT1KDM4ELMNATP53NPC1 | |
| SCHEMBL13911004 | 0.88 | GOT1 (0.42) | GOT1KDM4ELMNATP53NPC1 | |
| SCHEMBL29696261 | 0.87 | KDM4E (0.52) | GOT1KDM4ELMNATP53NPC1 | |
| SCHEMBL1993381 | 0.87 | KDM4E (0.52) | GOT1KDM4ELMNATP53NPC1 | |
| SCHEMBL31609343 | 0.84 | KDM4E (0.70) | KDM4ELMNATP53NPC1RAB9A | |
| SCHEMBL322178 | 0.84 | KDM4E (0.70) | KDM4ELMNATP53NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114302886-B | Triazolopyridazine derivative, preparation method, pharmaceutical composition and application thereof | 上海赛默罗生物科技有限公司 | 2024-03-22 | — | — | CN | disclosed |