SCHEMBL322178

SCHEMBL322178

c1ccc(-c2cccnn2)nc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 7/20 0.70
NPC1 O15118 6/20 0.70
RAB9A P51151 5/20 0.70
TP53 P04637 4/20 0.70
SMN1; SMN2 Q16637 4/20 0.70
LMNA P02545 3/20 0.70
HTT P42858 3/20 0.70
ALOX15 P16050 2/20 0.70
L3MBTL1 Q9Y468 2/20 0.70
ALDH1A1 P00352 1/20 0.70
PKM P14618 1/20 0.70
HPGD P15428 1/20 0.70
HSD17B10 Q99714 1/20 0.70
CCR1 P32246 3/20 0.67
CCR5 P51681 3/20 0.67
CCR8 P51685 3/20 0.67
CYP1A2 P05177 1/20 0.67
POLB P06746 1/20 0.67
METAP1 P53582 1/20 0.67
BLM P54132 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31609343 1.00 KDM4E (0.70) KDM4ENPC1RAB9ATP53SMN1; SMN2
Hydrogen Sulfide SCHEMBL3749800 0.98 KDM4E (0.67) KDM4ENPC1RAB9ATP53SMN1; SMN2
Water SCHEMBL3749603 0.98 KDM4E (0.67) KDM4ENPC1RAB9ATP53SMN1; SMN2
SCHEMBL1993381 0.88 KDM4E (0.52) KDM4ENPC1RAB9ATP53SMN1; SMN2
SCHEMBL29696261 0.88 KDM4E (0.52) KDM4ENPC1RAB9ATP53SMN1; SMN2
Dipyridyl SCHEMBL4909534 0.85 KDM4E (0.82) KDM4ENPC1RAB9ATP53SMN1; SMN2
SCHEMBL30792004 0.84 GOT1 (0.46) KDM4ENPC1RAB9ATP53SMN1; SMN2
SCHEMBL1456807 0.84 GOT1 (0.46) KDM4ENPC1RAB9ATP53SMN1; SMN2
SCHEMBL29442588 0.84 GOT1 (0.46) KDM4ENPC1RAB9ATP53SMN1; SMN2
SCHEMBL1456153 0.82 KDM4E (1.00) KDM4ENPC1RAB9ATP53SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117143074-A 3-benzyloxy-6-pyridylpyridazine compound as well as preparation method and application thereof 四川大学 2023-12-01 CN claimed
CN-115458749-A Composite negative current collector and preparation method thereof 扬州纳力新材料科技有限公司 2022-12-09 CN claimed
CN-115312971-A Polymer film, preparation method thereof and composite current collector 江阴纳力新材料科技有限公司 2022-11-08 CN claimed
EP-2069345-A2 PYRIDAZINE AND PYRROLE COMPOUNDS, PROCESSES FOR OBTAINING THEM AND USES Centre National de la Recherche Scientifique (CNRS) (FR) 2009-06-17 EP claimed
US-20090036418-A1 Pharmaceutical composition for treatment of cancer containing pyridylpyridazine or transition metal complex thereof as active ingredient INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY, THE (KR) 2009-02-05 US claimed
WO-2008012440-A2 PYRIDAZINE AND PYRROLE COMPOUNDS, PROCESSES FOR OBTAINING THEM AND USES CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) 2008-01-31 WO claimed
WO-2007007943-A1 PHARMACEUTICAL COMPOSITION FOR TREATING OF CANCER COMPRISING PYRIDYLPYRIDAZINE COMPOUNDS OR THEIR TRANSITION METAL COMPLEXES THE INDUSTRY AND ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC) (KR) 2007-01-18 WO claimed
US-4764454-A Color photographic material with color forming ligand compounds and a method of processing FUJI PHOTO FILM CO., LTD. (JP) 1988-08-16 US claimed
US-20250388587-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN SHANGHAI INC (CN) 2025-12-25 US disclosed
EP-4230708-A1 LIGHT-EMITTING DEVICE AND USE THEREOF IN DISPLAY Zhejiang Brilliant Optoelectronic Technology Co., Ltd. (CN) 2023-08-23 EP disclosed
US-20230255101-A1 Tetradentate Metal Complexes with Carbon Group Bridging Ligands UNIV ARIZONA STATE (US) 2023-08-10 US disclosed
CN-115458749-A Composite negative current collector and preparation method thereof 扬州纳力新材料科技有限公司 2022-12-09 CN disclosed
CN-115312971-A Polymer film, preparation method thereof and composite current collector 江阴纳力新材料科技有限公司 2022-11-08 CN disclosed
EP-3747915-A1 USE OF QUATERNISED NITROGEN COMPOUNDS AS GASOLINE ADDITIVES BASF SE (DE) 2020-12-09 EP disclosed
EP-0186869-A2 Colorless ligand-releasing monomers and polymers and their use to provide dyes with metal ions EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1986-07-09 EP disclosed
EP-0186870-A2 Photographic elements and processes utilizing imagewise reduction of ferric ions EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1986-07-09 EP disclosed
US-4568633-A THEN REACTING WITH COMPLEXING COMPOUND TO FORM DYE EASTMAN KODAK COMPANY (US) 1986-02-04 US disclosed
US-4557998-A AVOIDS COUPLER SOLVENTS EASTMAN KODAK COMPANY (US) 1985-12-10 US disclosed
US-4555478-A Photographic element and process for providing metal complex color images EASTMAN KODAK COMPANY (US) 1985-11-26 US disclosed
US-4555477-A Photographic element and process utilizing metal complex color masking dyes EASTMAN KODAK COMPANY (US) 1985-11-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250388587-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE ERBB2, MUSK, ERBB3 KDM4E 3350/4885NPC1 3254/4885RAB9A 3385/4885
US-20230255101-A1 Tetradentate Metal Complexes with Carbon Group Bridging Ligands STAU1, POLR1G, CLTC KDM4E 4613/4885NPC1 3632/4885RAB9A 1401/4885
US-20090036418-A1 Pharmaceutical composition for treatment of cancer containing pyridylpyridazine or transition metal complex thereof as active ingredient CA5A, PDCD11, PDCD1 KDM4E 1038/4885NPC1 4803/4885RAB9A 4415/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.