Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.36 |
| ▸ | EPRS1 | P07814 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | USP8 | P40818 | 1/20 | 0.35 |
| ▸ | USP7 | Q93009 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24717809 | 1.00 | NOTUM (0.37) | NOTUMMAP2K1KDM4EADRA2ACLCN2 | |
| SCHEMBL28363838 | 0.80 | CYP1A2 (0.52) | NOTUMKDM4ECYP1A2MEN1KMT2A | |
| SCHEMBL2080480 | 0.78 | CES2 (0.41) | NOTUMMAP2K1KDM4ETAS1R3TAS1R1 | |
| SCHEMBL14472134 | 0.77 | CYP1A2 (0.44) | NOTUMKDM4EADRA2ACLCN2EPRS1 | |
| SCHEMBL8090040 | 0.76 | TRPV4 (0.39) | KDM4ECYP1A2HIF1AUSP8USP7 | |
| SCHEMBL1192063 | 0.75 | CES2 (0.45) | NOTUMMAP2K1KDM4EADRA2ACLCN2 | |
| SCHEMBL30961765 | 0.74 | ALB (0.55) | NOTUMKDM4ETAS1R3TAS1R1TAS1R2 | |
| SCHEMBL28331532 | 0.74 | ALB (0.55) | NOTUMKDM4ETAS1R3TAS1R1TAS1R2 | |
| SCHEMBL3107355 | 0.74 | NOTUM (0.40) | NOTUMKDM4ECYP1A2MEN1KMT2A | |
| SCHEMBL15285575 | 0.73 | ALB (0.53) | KDM4EADRA2ACLCN2EPRS1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4323352-A1 | MODULATORS OF BCL6 PROTEOLYSIS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2024-02-21 | — | — | EP | disclosed |