Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | ADK | P55263 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL693684 | 0.82 | BCHE (0.47) | BCHENISCHKDM4EGSK3BCDK5 | |
| SCHEMBL1756320 | 0.80 | BCHE (0.33) | BCHENISCHGSK3BCDK5CDK5R1 | |
| SCHEMBL16516668 | 0.79 | KDM4E (0.31) | BCHEKDM4E | |
| SCHEMBL3002 | 0.79 | ALDH1A1 (0.41) | KDM4EGAAALDH1A1MAPTHPGD | |
| SCHEMBL315924 | 0.78 | KDM4E (0.50) | KDM4EALPLGAAGSK3BCDK5 | |
| SCHEMBL2353932 | 0.77 | METAP2 (0.47) | KDM4EALPLGAACDK5ALDH1A1 | |
| SCHEMBL4009432 | 0.77 | MAPT (0.38) | ALDH1A1MAPTHPGD | |
| SCHEMBL1965150 | 0.76 | RAB9A (0.48) | KDM4EGAAGSK3BALDH1A1MAPT | |
| SCHEMBL543407 | 0.75 | NPC1 (0.45) | NISCHKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL3177127 | 0.74 | ESR1 (0.43) | SMN1; SMN2TP53CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790741-B2 | Imidazothiazoles and imidazoxazoles | ABBOTT LABORATORIES (US) | 2010-09-07 | — | — | US | claimed |