Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 4/20 | 0.46 |
| ▸ | SORD | Q00796 | 2/20 | 0.40 |
| ▸ | AKT1 | P31749 | 2/20 | 0.39 |
| ▸ | AKT2 | P31751 | 2/20 | 0.39 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.34 |
| ▸ | CCR4 | P51679 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30808227 | 0.96 | MET (0.46) | METSORDAKT1AKT2AKT3 | |
| SCHEMBL30808200 | 0.88 | MET (0.41) | METSORDAKT1AKT2AKT3 | |
| SCHEMBL30808201 | 0.79 | MET (0.49) | METKDM4EGAAL3MBTL1TDP1 | |
| SCHEMBL30808207 | 0.78 | MET (0.44) | METKDM4EGAACRHBPCRHR2 | |
| SCHEMBL30808162 | 0.77 | SMN1; SMN2 (0.48) | METAKT1AKT2AKT3KDM4E | |
| SCHEMBL30808192 | 0.77 | MET (0.50) | METKDM4EGAAL3MBTL1TDP1 | |
| SCHEMBL30808197 | 0.74 | MET (0.50) | METKDM4EGAAL3MBTL1TDP1 | |
| SCHEMBL30808182 | 0.74 | MET (0.45) | METSORDKDM4ECNR2PIK3CA | |
| SCHEMBL18739111 | 0.74 | PIK3CD (0.43) | SORDSMN1; SMN2PIK3CAPIK3CDPIK3CB | |
| SCHEMBL30762614 | 0.73 | KDM4E (0.42) | AKT1AKT2AKT3KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024026419-A1 | QUINOXALINE DERIVATIVES AS PIK3 ALPHA MODULATORS | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2024-02-01 | — | — | WO | disclosed |