Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10649933 | 1.00 | ALDH1A1 (0.48) | ALDH1A1CYP3A4CYP2C9CYP2C19TSHR | |
| SCHEMBL10648891 | 0.89 | TSHR (0.48) | ALDH1A1CYP3A4CYP2C9CYP2C19TSHR | |
| SCHEMBL10653259 | 0.85 | MEN1 (0.40) | ALDH1A1CYP3A4CYP2C9CYP2C19TSHR | |
| SCHEMBL30808645 | 0.83 | LMNA (0.54) | ALDH1A1MEN1GSK3AGSK3BKMT2A | |
| SCHEMBL10509738 | 0.83 | LMNA (0.54) | ALDH1A1MEN1GSK3AGSK3BKMT2A | |
| SCHEMBL30808603 | 0.83 | MEN1 (0.50) | ALDH1A1CYP3A4CYP2C9CYP2C19TSHR | |
| SCHEMBL10511510 | 0.83 | ALDH1A1 (0.56) | ALDH1A1MEN1GSK3AGSK3BKMT2A | |
| SCHEMBL10650996 | 0.82 | NPSR1 (0.70) | ALDH1A1CYP3A4CYP2C9CYP2C19KMT2A | |
| SCHEMBL10511825 | 0.80 | LMNA (0.51) | MEN1KMT2AMAPTNPSR1LMNA | |
| SCHEMBL30808619 | 0.80 | NPSR1 (0.67) | ALDH1A1TSHRMEN1GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023250002-A1 | IDENTIFICATION OF NOVEL BENZOTHIAZONES AS TAU-SH3 INTERACTION INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | SOUTHERN RESEARCH INSTITUTE (US) | 2023-12-28 | — | — | WO | disclosed |