Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 4/20 | 0.36 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10652752 | 0.89 | HSD17B3 (0.44) | MEN1KMT2AGSK3AGSK3BCYP1A2 | |
| SCHEMBL10649933 | 0.85 | ALDH1A1 (0.48) | MEN1KMT2AGSK3AGSK3BALDH1A1 | |
| SCHEMBL30808596 | 0.85 | ALDH1A1 (0.48) | MEN1KMT2AGSK3AGSK3BALDH1A1 | |
| SCHEMBL10511618 | 0.84 | LMNA (0.45) | MEN1KMT2AGSK3AGSK3BCYP1A2 | |
| SCHEMBL10511348 | 0.83 | FPR2 (0.48) | MEN1KMT2AGSK3AGSK3BCYP1A2 | |
| SCHEMBL10507993 | 0.81 | HSD17B10 (0.44) | MEN1KMT2AHSD17B10ALDH1A1CYP3A4 | |
| SCHEMBL4971828 | 0.80 | NPSR1 (0.48) | MEN1KMT2AGSK3AGSK3BCYP1A2 | |
| SCHEMBL10509865 | 0.78 | MEN1 (0.42) | MEN1KMT2AGSK3AGSK3BCYP1A2 | |
| SCHEMBL10509886 | 0.76 | HSD17B3 (0.44) | MEN1KMT2AGSK3AGSK3BCYP1A2 | |
| SCHEMBL10511482 | 0.75 | CHRM2 (0.45) | MEN1KMT2ACYP1A2ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4755509-A | Heterocyclic aldose reductase inhibitors and methods of using them | Carbipem (FR) | 1988-07-05 | — | — | US | disclosed |