Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 15/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | DAO | P14920 | 2/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | PRKCG | P05129 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24098812 | 1.00 | PARP1 (0.65) | PARP1TP53DAOPDE3BPDE3A | |
| SCHEMBL30363048 | 0.90 | PARP1 (0.54) | PARP1TP53DAOPDE3BPDE3A | |
| SCHEMBL30363017 | 0.87 | PARP1 (0.65) | PARP1TP53DAOALDH1A1RXFP1 | |
| SCHEMBL9106684 | 0.87 | PARP1 (0.65) | PARP1TP53DAOALDH1A1RXFP1 | |
| SCHEMBL1133601 | 0.79 | PARP1 (1.00) | PARP1TP53DAOALDH1A1RXFP1 | |
| SCHEMBL29673205 | 0.79 | PARP1 (1.00) | PARP1TP53DAOALDH1A1RXFP1 | |
| SCHEMBL31492151 | 0.73 | PARP1 (0.50) | PARP1TP53DAOCDC7PLK4 | |
| SCHEMBL30809703 | 0.71 | PDE2A (0.67) | PARP1TP53DAOPDE3BPDE3A | |
| SCHEMBL8566230 | 0.71 | PDE2A (0.67) | PARP1TP53DAOPDE3BPDE3A | |
| SCHEMBL2429766 | 0.71 | PARP1 (0.65) | PARP1TP53DAOCDC7PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12551580-B2 | Heterocyclic compounds and imaging agents for imaging Huntington protein | CHDI FOUNDATION, INC. (US) | 2026-02-17 | — | — | US | disclosed |
| US-20240342317-A1 | HETEROCYCLIC COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2024-10-17 | — | — | US | disclosed |
| US-11918662-B2 | Heterocyclic compounds and imaging agents for imaging huntingtin protein | CHDI FOUNDATION, INC. (US) | 2024-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11918662-B2 | Heterocyclic compounds and imaging agents for imaging huntingtin protein | HTT, HYPK, HSPBP1 | PARP1 3115/4885TP53 142/4885DAO 3407/4885 |
| US-12551580-B2 | Heterocyclic compounds and imaging agents for imaging Huntington protein | HTT, HYPK, HIRA | PARP1 4072/4885TP53 1666/4885DAO 1082/4885 |
| US-20240342317-A1 | HETEROCYCLIC COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | HTT, HYPK, HSPBP1 | PARP1 3115/4885TP53 142/4885DAO 3407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.