Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 8/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 7/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 2/20 | 0.32 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.32 |
| ▸ | CKS1B | P61024 | 1/20 | 0.31 |
| ▸ | SKP1 | P63208 | 1/20 | 0.31 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31514889 | 0.88 | DDB1 (0.42) | CRBNDDB1GAABRD4HSD11B1 | |
| SCHEMBL31726146 | 0.74 | CCR5 (0.38) | GAACCR5JAK2JAK1JAK3 | |
| SCHEMBL17591811 | 0.72 | CTSK (0.54) | GAABRD4HSD11B1CYP2C9CTSK | |
| SCHEMBL12367685 | 0.69 | GAA (0.55) | CRBNDDB1GAA | |
| SCHEMBL2176628 | 0.69 | GAA (0.55) | CRBNDDB1GAA | |
| SCHEMBL25169537 | 0.66 | DDB1 (0.59) | CRBNDDB1GAACKS1BSKP1 | |
| SCHEMBL27252628 | 0.66 | DDB1 (0.51) | CRBNDDB1KCNA3 | |
| SCHEMBL29160932 | 0.66 | CTSK (0.58) | CCR5JAK2JAK1JAK3BRD4 | |
| SCHEMBL29160931 | 0.66 | CTSK (0.58) | CCR5JAK2JAK1JAK3BRD4 | |
| SCHEMBL24873296 | 0.64 | BTK (0.51) | CRBNDDB1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543861-A1 | BIFUNCTIONAL COMPOUNDS CONTAINING PYRIMIDINE DERIVATIVES FOR DEGRADING CYCLIN-DEPENDENT KINASE 2 VIA UBIQUITIN PROTEASOME PATHWAY | Nikang Therapeutics, Inc. (US) | 2025-04-30 | — | — | EP | disclosed |
| WO-2023249970-A1 | BIFUNCTIONAL COMPOUNDS CONTAINING PYRIMIDINE DERIVATIVES FOR DEGRADING CYCLIN-DEPENDENT KINASE 2 VIA UBIQUITIN PROTEASOME PATHWAY | NIKANG THERAPEUTICS, INC. (US) | 2023-12-28 | — | — | WO | disclosed |