Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 1/20 | 0.44 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.44 |
| ▸ | ITGAL | P20701 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | NMT1 | P30419 | 3/20 | 0.40 |
| ▸ | NMT2 | O60551 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3081386 | 1.00 | ITGB2 (0.44) | ITGB2ICAM1ITGALS1PR1MEN1 | |
| SCHEMBL6031320 | 0.88 | KDM4E (0.57) | ITGB2ICAM1ITGALS1PR1ALDH1A1 | |
| SCHEMBL6031317 | 0.88 | KDM4E (0.57) | ITGB2ICAM1ITGALS1PR1ALDH1A1 | |
| SCHEMBL15669061 | 0.87 | MEN1 (0.54) | MEN1HSP90AA1KMT2AALDH1A1HDAC8 | |
| SCHEMBL15669064 | 0.87 | MEN1 (0.54) | MEN1HSP90AA1KMT2AALDH1A1HDAC8 | |
| SCHEMBL13179954 | 0.86 | ALOX5 (0.42) | MEN1KMT2AHDAC8MAPTPPARG | |
| SCHEMBL3115040 | 0.85 | MEN1 (0.48) | MEN1HSP90AA1KMT2AALDH1A1KDM4E | |
| SCHEMBL3303621 | 0.85 | PTGS2 (0.42) | ITGALMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL3303627 | 0.85 | PTGS2 (0.42) | ITGALMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL3085911 | 0.80 | MAOB (0.52) | ITGB2ICAM1ITGALS1PR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1806338-B1 | PROCESS FOR PRODUCING 2-AMINO-2-[2-[4-(3-BENZYLOXY-PHENYLTHIO)-2-CHLOROPHENYL[ETHYL]-1,3-PROPANEDIOL HYDROCHLORIDE AND HYDRATES THEREOF. AND INTERMEDIATES THE PRODUCTION THEREOF | KYORIN SEIYAKU KK (JP) | 2016-01-20 | — | — | EP | claimed |
| US-7795472-B2 | Process for producing 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl]-1,3-propanediol hydrochloride and hydrates thereof, and intermediates in the production thereof | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2010-09-14 | — | — | US | claimed |
| US-20080207941-A1 | Process for Producing 2-Amino-2-[2-[4-(3-Benzyloxyphenylthio)-2-Chlorophenyl]Ethyl]-1,3-Propanediol Hydrochloride and Hydrates Thereof, and Intermediates in the Production Thereof | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2008-08-28 | — | — | US | claimed |
| EP-1806338-A1 | PROCESS FOR PRODUCING 2-AMINO-2-[2-[4-(3-BENZYLOXYPHENYLTHIO)-2-CHLOROPHENYL[ETHYL]-1,3-PROPANEDIOL HYDROCHLORIDE OR HYDRATE THEREOF AND INTERMEDIATE FOR THE SAME | Kyorin Pharmaceutical Co., Ltd. (JP) | 2007-07-11 | — | — | EP | claimed |
| EP-2511262-B1 | PROCESS FOR PRODUCING 2-AMINO-2-[2-[4-(3-BENZYLOXY-PHENYLTHIO)-2-CHLOROPHENYL[ETHYL]-1,3-PROPANEDIOL HYDROCHLORIDE | KYORIN SEIYAKU KK (JP) | 2017-02-01 | — | — | EP | disclosed |
| EP-2511262-B1 | PROCESS FOR PRODUCING 2-AMINO-2-[2-[4-(3-BENZYLOXY-PHENYLTHIO)-2-CHLOROPHENYL[ETHYL]-1,3-PROPANEDIOL HYDROCHLORIDE | KYORIN SEIYAKU KK (JP) | 2017-02-01 | — | — | EP | disclosed |
| EP-1806338-B1 | PROCESS FOR PRODUCING 2-AMINO-2-[2-[4-(3-BENZYLOXY-PHENYLTHIO)-2-CHLOROPHENYL[ETHYL]-1,3-PROPANEDIOL HYDROCHLORIDE AND HYDRATES THEREOF. AND INTERMEDIATES THE PRODUCTION THEREOF | KYORIN SEIYAKU KK (JP) | 2016-01-20 | — | — | EP | disclosed |
| CN-101880250-B | Process for producing 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl]-1,3-propanediol hydrochloride or hydrate thereof and intermediate for the same | KYORIN SEIYAKU KK | 2013-04-03 | — | — | CN | disclosed |
| EP-2511262-A1 | PROCESS FOR PRODUCING 2-AMINO-2-[2-[4-(3-BENZYLOXY-PHENYLTHIO)-2-CHLOROPHENYL[ETHYL]-1,3-PROPANEDIOL HYDROCHLORIDE | Kyorin Pharmaceutical Co., Ltd. (JP) | 2012-10-17 | — | — | EP | disclosed |
| CN-101072752-B | Method for producing 2-amino-2- [2- [4- (3-benzyloxyphenylthio) -2-chlorophenyl ] ethyl ] -1, 3-propanediol hydrochloride or hydrate thereof and intermediate for producing same | KYORIN SEIYAKU KK | 2010-12-08 | — | — | CN | disclosed |
| US-7795472-B2 | Process for producing 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl]-1,3-propanediol hydrochloride and hydrates thereof, and intermediates in the production thereof | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2010-09-14 | — | — | US | disclosed |
| US-7795472-B2 | Process for producing 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl]-1,3-propanediol hydrochloride and hydrates thereof, and intermediates in the production thereof | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2010-09-14 | — | — | US | disclosed |
| US-20080207941-A1 | Process for Producing 2-Amino-2-[2-[4-(3-Benzyloxyphenylthio)-2-Chlorophenyl]Ethyl]-1,3-Propanediol Hydrochloride and Hydrates Thereof, and Intermediates in the Production Thereof | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2008-08-28 | — | — | US | disclosed |
| US-20080207941-A1 | Process for Producing 2-Amino-2-[2-[4-(3-Benzyloxyphenylthio)-2-Chlorophenyl]Ethyl]-1,3-Propanediol Hydrochloride and Hydrates Thereof, and Intermediates in the Production Thereof | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2008-08-28 | — | — | US | disclosed |
| CN-101072752-A | Method for producing 2-amino-2- [ 2- [ 4- (3-benzyloxyphenylthio) -2-chlorophenyl ] ethyl ] -1, 3-propanediol hydrochloride or hydrate thereof and intermediate for producing same | KYORIN SEIYAKU KK (JP) | 2007-11-14 | — | — | CN | disclosed |
| EP-1806338-A1 | PROCESS FOR PRODUCING 2-AMINO-2-[2-[4-(3-BENZYLOXYPHENYLTHIO)-2-CHLOROPHENYL[ETHYL]-1,3-PROPANEDIOL HYDROCHLORIDE OR HYDRATE THEREOF AND INTERMEDIATE FOR THE SAME | Kyorin Pharmaceutical Co., Ltd. (JP) | 2007-07-11 | — | — | EP | disclosed |
| EP-1806338-A1 | PROCESS FOR PRODUCING 2-AMINO-2-[2-[4-(3-BENZYLOXYPHENYLTHIO)-2-CHLOROPHENYL[ETHYL]-1,3-PROPANEDIOL HYDROCHLORIDE OR HYDRATE THEREOF AND INTERMEDIATE FOR THE SAME | Kyorin Pharmaceutical Co., Ltd. (JP) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006041019-A1 | PROCESS FOR PRODUCING 2-AMINO-2-[2-[4-(3-BENZYLOXYPHENYLTHIO)-2-CHLOROPHENYL]ETHYL]-1,3-PROPANEDIOL HYDROCHLORIDE OR HYDRATE THEREOF AND INTERMEDIATE FOR THE SAME | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2006-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207941-A1 | Process for Producing 2-Amino-2-[2-[4-(3-Benzyloxyphenylthio)-2-Chlorophenyl]Ethyl]-1,3-Propanediol Hydrochloride and Hydrates Thereof, and Intermediates in the Production Thereof | NAT1, ACR, NOD1 | ITGB2 3078/4885ICAM1 436/4885ITGAL 4519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.