Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 2/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.37 |
| ▸ | MLKL | Q8NB16 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | GABRD | O14764 | 2/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30816897 | 1.00 | SOS1 (0.40) | SOS1CRBNMLKLTNKSPARP1 | |
| SCHEMBL30816863 | 0.94 | SOS1 (0.42) | SOS1CRBNMLKLTNKSPARP1 | |
| SCHEMBL30816861 | 0.94 | SOS1 (0.42) | SOS1CRBNMLKLTNKSPARP1 | |
| SCHEMBL30816917 | 0.87 | CRBN (0.35) | CRBNTNKSPARP1PARP10TNKS2 | |
| SCHEMBL28978031 | 0.86 | CRBN (0.42) | CRBNTNKSPARP1PARP10TNKS2 | |
| SCHEMBL30266960 | 0.86 | CRBN (0.42) | CRBNTNKSPARP1PARP10TNKS2 | |
| SCHEMBL31722472 | 0.85 | NR3C1 (0.43) | TNKSPARP1PARP10TNKS2NR3C1 | |
| SCHEMBL25581205 | 0.85 | NR3C1 (0.43) | TNKSPARP1PARP10TNKS2NR3C1 | |
| SCHEMBL30816865 | 0.85 | TNKS (0.37) | SOS1CRBNTNKSPARP1PARP10 | |
| SCHEMBL30864019 | 0.85 | ITGB3 (0.37) | CRBNTNKSPARP1PARP10TNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4631942-A1 | PAN-KRAS DEGRADING AGENT, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Leadingtac Pharmaceutical (Shaoxing) Co., Ltd. (CN) | 2025-10-15 | — | — | EP | disclosed |
| CN-117917410-A | Pan-KRAS degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2024-04-23 | — | — | CN | disclosed |
| CN-117917416-A | KRAS G12D degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2024-04-23 | — | — | CN | disclosed |