Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28978062 | 0.89 | MGLL (0.39) | ITGB3ITGA2BMGLLGABRDGABRA1 | |
| SCHEMBL28978031 | 0.89 | CRBN (0.42) | ITGB3ITGA2BGABRDGABRA1GABRB1 | |
| SCHEMBL30266960 | 0.89 | CRBN (0.42) | ITGB3ITGA2BGABRDGABRA1GABRB1 | |
| SCHEMBL30816865 | 0.89 | TNKS (0.37) | ITGB3ITGA2BGABRDGABRA1GABRB1 | |
| SCHEMBL30816917 | 0.87 | CRBN (0.35) | ITGB3ITGA2BGABRDGABRA1GABRB1 | |
| SCHEMBL30816863 | 0.87 | SOS1 (0.42) | CRBNTNKSPARP1PARP10TNKS2 | |
| SCHEMBL30816861 | 0.87 | SOS1 (0.42) | CRBNTNKSPARP1PARP10TNKS2 | |
| SCHEMBL30816897 | 0.85 | SOS1 (0.40) | ITGB3ITGA2BGABRDGABRA1GABRB1 | |
| SCHEMBL30816892 | 0.85 | SOS1 (0.40) | ITGB3ITGA2BGABRDGABRA1GABRB1 | |
| SCHEMBL24670711 | 0.80 | HSD11B1 (0.43) | MGLLCRBNMAPK1DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4606803-A1 | KRAS G12D DEGRADATION AGENT, AND PREPARATION METHOD AND USE THEREFOR | Leadingtac Pharmaceutical (Shaoxing) Co., Ltd. (CN) | 2025-08-27 | — | — | EP | disclosed |
| CN-119948027-A | SOS1 protein degradation agent and application thereof | 领泰生物医药(绍兴)有限公司 | 2025-05-06 | — | — | CN | disclosed |
| CN-117917416-A | KRAS G12D degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2024-04-23 | — | — | CN | disclosed |