Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.42 |
| ▸ | SNCA | P37840 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 3/20 | 0.37 |
| ▸ | KLK1 | P06870 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9323451 | 0.75 | SNCA (0.58) | KLKB1ALOX15SNCAKMT2AMAPT | |
| SCHEMBL4758489 | 0.74 | ALDH1A1 (0.72) | ALDH1A1GFERALOX15KMT2AMAPT | |
| SCHEMBL3138003 | 0.70 | MEN1 (0.48) | NPC1RAB9AKMT2AMEN1GAA | |
| SCHEMBL9806582 | 0.69 | KLKB1 (0.62) | ALDH1A1GFERKLKB1ALOX15NPC1 | |
| SCHEMBL6315569 | 0.69 | KLKB1 (0.77) | ALDH1A1KLKB1RAB9ASNCAKMT2A | |
| SCHEMBL9321322 | 0.69 | SNCA (0.60) | NPC1MITFXBP1RAB9ANPSR1 | |
| SCHEMBL2270561 | 0.69 | LMNA (0.68) | ALDH1A1GFERKLKB1ALOX15SNCA | |
| SCHEMBL23484439 | 0.67 | ALDH1A1 (0.69) | ALDH1A1GFERALOX15KMT2AMAPT | |
| SCHEMBL7898215 | 0.67 | ALDH1A1 (0.59) | ALDH1A1GFERALOX15KMT2AMAPT | |
| SCHEMBL24203607 | 0.66 | POLB (0.79) | NPC1RAB9ASNCAKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100261788-A1 | Inhibition of Bid-Induced Cell-Death Using Small Organic Molecules | THE BURNHAM INSTITUTE | 2010-10-14 | — | — | US | disclosed |
| US-20100261788-A1 | Inhibition of Bid-Induced Cell-Death Using Small Organic Molecules | THE BURNHAM INSTITUTE | 2010-10-14 | — | — | US | disclosed |
| US-7741521-B2 | 4-phenylsulfanyl-phenylamine derivatives used as BH3 Interacting Domain Death Antagonist (BID), for the treatment of neurodegenerative diseases, liver inflammation, multiple sclerosis, heart disease, ischemic injury and for controlling apoptotic cascade | THE BURNHAM INSTITUTE (US) | 2010-06-22 | — | — | US | disclosed |
| US-7741521-B2 | 4-phenylsulfanyl-phenylamine derivatives used as BH3 Interacting Domain Death Antagonist (BID), for the treatment of neurodegenerative diseases, liver inflammation, multiple sclerosis, heart disease, ischemic injury and for controlling apoptotic cascade | THE BURNHAM INSTITUTE (US) | 2010-06-22 | — | — | US | disclosed |
| US-20070185196-A1 | Inhibitionof bid-induced cell-death using small organic moleculeus | THE BURNHAM INSTITUTE (US) | 2007-08-09 | — | — | US | disclosed |
| US-20070185196-A1 | Inhibitionof bid-induced cell-death using small organic moleculeus | THE BURNHAM INSTITUTE (US) | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185196-A1 | Inhibitionof bid-induced cell-death using small organic moleculeus | BID, BAD, TMBIM6 | ALDH1A1 4595/4885GFER 3437/4885KLKB1 4583/4885 |
| US-20100261788-A1 | Inhibition of Bid-Induced Cell-Death Using Small Organic Molecules | BID, BAD, TMBIM6 | ALDH1A1 4719/4885GFER 4436/4885KLKB1 4435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.