Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | TYK2 | P29597 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25333075 | 0.73 | SSTR4 (0.40) | KDM4EHTTALDH1A1HPGD | |
| SCHEMBL15432302 | 0.71 | TGFBR1 (0.37) | — | |
| SCHEMBL16906805 | 0.71 | TGFBR1 (0.37) | KDM4EALDH1A1HPGD | |
| SCHEMBL24729111 | 0.71 | CA12 (0.34) | POLBALDH1A1 | |
| SCHEMBL19659000 | 0.71 | RIPK1 (0.47) | — | |
| SCHEMBL24729109 | 0.70 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL12408124 | 0.70 | SMN1; SMN2 (0.32) | KDM4EHTTSMN1; SMN2ALDH1A1PIK3CA | |
| SCHEMBL15451930 | 0.68 | PARP2 (0.41) | KDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL24729110 | 0.68 | ALDH1A1 (0.31) | POLBALDH1A1 | |
| SCHEMBL24729048 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3760625-B1 | BICYCLIC LACTAMS AS RECEPTOR-INTERACTING PROTEIN-1 (RIP1) KINASE INHIBITORS FOR TREATING E.G. INFLAMMATORY DISEASES | HOFFMANN LA ROCHE (CH) | 2024-03-27 | — | — | EP | claimed |